Fanconi anemia (cross)linked to DNA repair

Academic Article

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Overview

authors

• Niedernhofer, Laura
• Lalai, A. S.
• Hoeijmakers, J. H. J.

publication date

• December 2005

journal

• Cell  Journal

abstract

• Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.

subject areas

• Basic-Leucine Zipper Transcription Factors
• DNA Helicases
• DNA Repair
• Fanconi Anemia
• Fanconi Anemia Complementation Group Proteins
• Humans

Identity

International Standard Serial Number (ISSN)

• 0092-8674

Digital Object Identifier (DOI)

• 10.1016/j.cell.2005.12.009

PubMed ID

• 16377561

Additional Document Info

start page

• 1191

end page

• 1198

volume

• 123

issue

• 7