recent publications

• academic article

  • Gentry, P. R., Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., et al. Development of a highly potent, novel M(5) positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)pipe ridine-4-carboxamide (ML380) Journal of Medicinal Chemistry  2014 57:7804-7810  DOI:10.1021/jm500995y  PMID:25147929  PMCID:PMC4175000
  • Gentry, P. R., Kokubo, M., Bridges, T. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Utley, T. J., Rajapakse, A., Byers, F., Niswender, C. M., Morrison, R. D., et al. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe ChemMedChem  2014 9:1677-1682  DOI:10.1002/cmdc.201402051  PMID:24692176  PMCID:PMC4116439
  • Gentry, P. R., Bridges, T. M., Lamsal, A., Vinson, P. N., Smith, E., Chase, P., Hodder, P. S., Engers, J. L., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R., et al. Discovery of ML326: The first sub-micromolar, selective M-5 PAM Bioorganic & Medicinal Chemistry Letters  2013 23:2996-3000  DOI:10.1016/j.bmcl.2013.03.032  PMID:23562060  PMCID:PMC3634896
  • Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., et al. Discovery of N-(benzo 1,2,3 triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding Bioorganic & Medicinal Chemistry Letters  2013 23:6172-6177  DOI:10.1016/j.bmcl.2013.08.112  PMID:24080461  PMCID:PMC3878165
  • Gentry, P. R., Kokubo, M., Bridges, T. M., Kett, N. R., Harp, J. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., et al. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375) Journal of Medicinal Chemistry  2013 56:9351-9355  DOI:10.1021/jm4013246  PMID:24164599  PMCID:PMC3876027
  • Niedernhofer, L. J., Daniels, J. S., Rouzer, C. A., Greene, R. E., Marnett, L. J. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells Journal of Biological Chemistry  2003 278:31426-31433  DOI:10.1074/jbc.M212549200  PMID:12775726