Enantioselective synthesis of the C1-C11 fragment of tedanolide C

Academic Article
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publication date

  • January 2013

abstract

  • A convergent synthesis of the protected C(1)-C(11) fragment 6 of the targeted enantiomer of tedanolide C is described. The key step of the synthesis is the Felkin-Ahn addition of vinyl iodide 7 to aldehyde 8 that proceeds in 80% yield with 4:1 diastereoselectivity.