Enantioselective synthesis of the C1-C11 fragment of tedanolide C

Academic Article

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Overview

authors

• Geist, J. G.
• Barth, R.
• Roush, William

publication date

• 2013

journal

• Organic Letters  Journal

abstract

• A convergent synthesis of the protected C(1)-C(11) fragment 6 of the targeted enantiomer of tedanolide C is described. The key step of the synthesis is the Felkin-Ahn addition of vinyl iodide 7 to aldehyde 8 that proceeds in 80% yield with 4:1 diastereoselectivity.

subject areas

• Animals
• Macrolides
• Molecular Structure
• Porifera
• Stereoisomerism

Identity

PubMed Central ID

• PMC3539184

International Standard Serial Number (ISSN)

• 1523-7060

Digital Object Identifier (DOI)

• 10.1021/ol303089w

PubMed ID

• 23249423

Additional Document Info

start page

• 58

end page

• 61

volume

• 15

issue

• 1