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Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 h1n1 influenza pandemic

Academic Article
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Overview

authors

  • Xu, R.
  • Zhu, X. Y.
  • McBride, R.
  • Nycholat, C. M.
  • Yu, W. L.
  • Paulson, James
  • Wilson, Ian

publication date

  • September 2012

journal

  • Journal of Virology  Journal

abstract

  • The 2009 H1N1 influenza pandemic is the first human pandemic in decades and was of swine origin. Although swine are believed to be an intermediate host in the emergence of new human influenza viruses, there is still little known about the host barriers that keep swine influenza viruses from entering the human population. We surveyed swine progenitors and human viruses from the 2009 pandemic and measured the activities of the hemagglutinin (HA) and neuraminidase (NA), which are the two viral surface proteins that interact with host glycan receptors. A functional balance of these two activities (HA binding and NA cleavage) is found in human viruses but not in the swine progenitors. The human 2009 H1N1 pandemic virus exhibited both low HA avidity for glycan receptors as a result of mutations near the receptor binding site and weak NA enzymatic activity. Thus, a functional match between the hemagglutinin and neuraminidase appears to be necessary for efficient transmission between humans and may be an indicator of the pandemic potential of zoonotic viruses.

subject areas

  • Animals
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Humans
  • Influenza A Virus, H1N1 Subtype
  • Influenza, Human
  • Kinetics
  • Neuraminidase
  • Orthomyxoviridae Infections
  • Pandemics
  • Polysaccharides
  • Protein Binding
  • Receptors, Virus
  • Swine
  • Swine Diseases
  • Viral Proteins
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Identity

PubMed Central ID

  • PMC3416152

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.00697-12

PubMed ID

  • 22718832
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Additional Document Info

start page

  • 9221

end page

  • 9232

volume

  • 86

issue

  • 17

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