recent publications

• academic article

  • Keravala, A., Liu, D. X., Lechman, E. R., Wolfe, D., Nash, J. A., Lampe, D. J., Robbins, P. D. Hyperactive Himar1 transposase mediates transposition in cell culture and enhances gene expression in vivo Human Gene Therapy  2006 17:1006-1018  DOI:10.1089/hum.2006.17.1006  PMID:16989604
  • Kim, S. H., Bianco, N., Menon, R., Lechman, E. R., Shufesky, W. J., Morelli, A. E., Robbins, P. D. Exosomes derived from genetically modified dc expressing fasl are anti-inflammatory and immunosuppressive Molecular Therapy  2006 13:289-300  DOI:10.1016/j.ymthe.2005.09.015  PMID:16275099
  • Keravala, A., Lechman, E. R., Nash, J., Mi, Z. B., Robbins, P. D. Human, viral or mutant human il-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis Arthritis Research & Therapy  2006 8:R91  DOI:10.1186/ar1960  PMID:16704745  PMCID:PMC1779418
  • Kim, S. H., Lechman, E. R., Bianco, N., Menon, R., Keravala, A., Nash, J., Mi, Z. B., Watkins, S. C., Gambotto, A., Robbins, P. D. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis Journal of Immunology  2005 174:6440-6448  PMID:15879146
  • Lechman, E. R., Keravala, A., Nash, J., Kim, S. H., Mi, Z., Robbins, P. D. The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen Gene Therapy  2003 10:2029-2035  DOI:10.1038/sj.gt.3302109  PMID:14566362
  • Mi, Z. B., Lu, X. L., Mai, J. C., Bobby, G. N., Wang, G. Q., Lechman, E. R., Watkins, S. C., Rabinowich, H., Robbins, P. D. Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium Molecular Therapy  2003 8:295-305  DOI:10.1016/s1525-016(03)00181-3  PMID:12907152
  • Kim, S. H., Lechman, E. R., Kim, S., Nash, J., Oligino, T. J., Robbins, P. D. Ex vivo gene delivery of il-1ra and soluble tnf receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis Molecular Therapy  2002 6:591-600  DOI:10.1006/mthe.2002.0711  PMID:12409257
  • Mi, Z. B., Ghivizzani, S. C., Lechman, E. R., Jaffurs, D., Glorioso, J. C., Evans, C. H., Robbins, P. D. Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints Arthritis and Rheumatism  2000 43:2563-2570  DOI:10.1002/1529-0131(200011)43:11<2563::aid-anr25>3.0.co;2-8  PMID:11083281
  • Oligino, T., Ghivizzani, S. C., Wolfe, D., Lechman, E. R., Krisky, D., Mi, Z., Evans, C. H., Robbins, P. D., Glorioso, J. C. Intra-articular delivery of a herpes simplex virus il-1ra gene vector reduces inflammation in a rabbit model of arthritis Gene Therapy  1999 6:1713-1720  DOI:10.1038/sj.gt.3301014  PMID:10516720
  • Lechman, E. R., Jaffurs, D., Ghivizzani, S. C., Gambotto, A., Kovesdi, I., Mi, Z. B., Evans, C. H., Robbins, P. D. Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees Journal of Immunology  1999 163:2202-2208  PMID:10438962
  • Ghivizzani, S. C., Lechman, E. R., Kang, R., Tio, C., Kolls, J., Evans, C. H., Robbins, P. D. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects Proceedings of the National Academy of Sciences of the United States of America  1998 95:4613-4618  DOI:10.1073/pnas.95.8.4613  PMID:9539786
  • Ghivizzani, S. C., Kang, R., Georgescu, H. I., Lechman, E. R., Jaffurs, D., Engle, J. M., Watkins, S. C., Tindal, M. H., Suchanek, M. K., McKenzie, L. R., Evans, C. H., Robbins, P. D. Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis Journal of Immunology  1997 159:3604-3612  PMID:9317160
  • Ghivizzani, S. C., Lechman, E. R., Tio, C., Mule, K. M., Chada, S., McCormack, J. E., Evans, C. H., Robbins, P. D. Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: Implications for arthritis gene therapy Gene Therapy  1997 4:977-982  DOI:10.1038/sj.gt.3300486  PMID:9349435