Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Prodynorphin allelic distribution in scandinavian chronic alcoholics

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Geijer, T.
  • Jonsson, E.
  • Neiman, J.
  • Gyllander, A.
  • Sedvall, G.
  • Rydberg, U.
  • Terenius, Lars

publication date

  • October 1997

journal

  • Alcoholism-Clinical and Experimental Research  Journal

abstract

  • Two regions of the human prodynorphin gene, the exon 4-region coding for the opioid peptides and the putative promotor/exon 1-region were analyzed for possible presence of polymorphisms. No polymorphism was detected in the exon 4-region, whereas a GC/AT base-pair exchange was observed 301 base pairs upstream of the exon 1/intron A boundary. This polymorphic marker was examined in Scandinavian chronic alcoholics (n = 70) and control subjects (n = 55). Prodynorphin allelic distributions were not significantly different in alcoholic patients and control subjects. The results suggest that no major influence on alcoholism is exerted through genes associated with this prodynorphin allelic marker.

subject areas

  • Adult
  • Aged
  • Alcoholism
  • Alleles
  • Base Composition
  • Enkephalins
  • Exons
  • Female
  • Genetic Markers
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Promoter Regions, Genetic
  • Protein Precursors
scroll to property group menus

Research

keywords

  • alcoholism
  • genetics
  • polymorphism
  • prodynorphin
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0145-6008

Digital Object Identifier (DOI)

  • 10.1097/00000374-199710000-00025

PubMed ID

  • 9347097
scroll to property group menus

Additional Document Info

start page

  • 1333

end page

  • 1336

volume

  • 21

issue

  • 7

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support