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Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer

Academic Article
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Overview

authors

  • Yi, C. L.
  • McCarty, J. H.
  • Troutman, S. A.
  • Eckman, M. S.
  • Bronson, R. T.
  • Kissil, Joseph

publication date

  • November 2005

journal

  • Molecular and Cellular Biology  Journal

abstract

  • The band 4.1 proteins are cytoskeletal proteins, harboring a conserved FERM domain highly homologous to the N-terminal FERM domain of ezrin, radixin, moesin, and merlin. Recently, a truncated form of the 4.1B protein, termed Dal-1, was identified in a screen as down regulated in adenocarcinoma of the lung and was mapped to chromosome 18p11.3, which is lost in 38% of primary non-small cell lung carcinoma tumors. Analysis of several meningiomas has shown that Dal-1 expression was lost in 76% of the tumors. To further elucidate the function of the 4.1B/Dal-1 gene in development and tumorigenesis we generated mice deficient for this allele. The 4.1B/Dal-1 null mice develop normally and are fertile. Rates of cellular proliferation and apoptosis in brain, mammary, and lung tissues from the 4.1B/Dal-1 null mice were indistinguishable from those seen with wild-type mice. Aging studies indicate that these mice do not have a propensity to develop tumors. Analysis of fibroblasts from these mice demonstrated that the growth characteristics and kinetics of these cells were not different from those of cells from the wild-type mice. These findings indicate that the 4.1B gene is not required for normal development and that 4.1B/Dal-1 does not function as a tumor suppressor gene.

subject areas

  • Alleles
  • Animals
  • Apoptosis
  • Blotting, Southern
  • Blotting, Western
  • Brain
  • Cell Death
  • Cell Proliferation
  • Cells, Cultured
  • Cloning, Molecular
  • Cytoskeletal Proteins
  • DNA Primers
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Immunohistochemistry
  • Kinetics
  • Lung
  • Mammary Glands, Animal
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Genetic
  • Mutation
  • Neoplasms
  • Polymerase Chain Reaction
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Identity

International Standard Serial Number (ISSN)

  • 0270-7306

Digital Object Identifier (DOI)

  • 10.1128/mcb.25.22.10052-10059.2005

PubMed ID

  • 16260618
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Additional Document Info

start page

  • 10052

end page

  • 10059

volume

  • 25

issue

  • 22

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