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Tyrosine hydroxylase allelic distribution in suicide attempters

Academic Article
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Overview

authors

  • Persson, M. L.
  • Wasserman, D.
  • Geijer, T.
  • Jonsson, E. G.
  • Terenius, Lars

publication date

  • September 1997

journal

  • Psychiatry Research  Journal

abstract

  • A tetranucleotide repeat polymorphism in the first intron of the tyrosine hydroxylase (TH) locus was examined in a group of 118 adult suicide attempters and 78 control subjects. The suicide attempters were diagnosed according to DSM-III-R criteria at the index attempt and represented the following diagnoses: major depression (18), dysthymia (13), anxiety disorders (16), adjustment disorders (29), psychoactive substance abuse disorders (27) and psychotic disorders (15). A significant variation in the prevalence of carriers of the TH-K3 allele (high for suicide attempters with adjustment disorders, P = 0.0023) and a tendency toward a variation of the TH-K1 allele (low among all suicide attempters, P = 0.046) was observed. In light of other data the variation of TH-K1 and TH-K3 suggests that these alleles may reflect predisposition for a common phenotype with altered vulnerability for psychiatric disorders.

subject areas

  • Adult
  • Alleles
  • Chromosome Mapping
  • Female
  • Genetic Carrier Screening
  • Humans
  • Introns
  • Male
  • Microsatellite Repeats
  • Middle Aged
  • Mood Disorders
  • Phenotype
  • Polymorphism, Genetic
  • Risk Factors
  • Substance-Related Disorders
  • Suicide, Attempted
  • Tyrosine 3-Monooxygenase
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Research

keywords

  • TH-K1 allele
  • TH-K3 allele
  • suicide attempters
  • tyrosine hydroxylase
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Identity

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/s0165-1781(97)00068-1

PubMed ID

  • 9335198
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Additional Document Info

start page

  • 73

end page

  • 80

volume

  • 72

issue

  • 2

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