related to degree

• Marciano, David, Ph.D. in Biology, Scripps Research 2010 - 2014

authors

• Pascal, B. D.
• Willis, S.
• Lauer, J. L.
• Landgraf, R. R.
• West, Graham
• Marciano, David
• Novick, S.
• Goswami, D.
• Chalmers, Michael
• Griffin, Patrick

publication date

• 2012

journal

• Journal of the American Society for Mass Spectrometry  Journal

abstract

• Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page http://hdx.florida.scripps.edu .

subject areas

• Algorithms
• Amino Acid Sequence
• Deuterium Exchange Measurement
• Molecular Sequence Data
• Peptides
• Proteins
• Reproducibility of Results
• Sequence Alignment
• Sequence Analysis, Protein
• Software
• Tandem Mass Spectrometry
• User-Computer Interface

keywords

• Automation
• H/D exchange
• HDX
• Mass spectrometry
• Protein dynamics
• Software

PubMed Central ID

• PMC3808162

International Standard Serial Number (ISSN)

• 1044-0305

Digital Object Identifier (DOI)

• 10.1007/s13361-012-0419-6

PubMed ID

• 22692830

start page

• 1512

end page

• 1521

volume

• 23

issue

• 9