Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

PTPN22 alters the development of regulatory T cells in the thymus

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Maine, C. J.
  • Hamilton-Williams, E. E.
  • Cheung, J.
  • Stanford, S. M.
  • Bottini, N.
  • Wicker, L. S.
  • Sherman, Linda

publication date

  • June 2012

journal

  • Journal of Immunology  Journal

abstract

  • PTPN22 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling in lymphocytes and is strongly linked with susceptibility to a number of autoimmune diseases. As strength of TCR signal is critical to the thymic selection of regulatory T cells (Tregs), we examined the effect of murine PTPN22 deficiency on Treg development and function. In the thymus, numbers of pre-Tregs and Tregs increased inversely with the level of PTPN22. This increase in Tregs persisted in the periphery and could play a key part in the reduced severity observed in the PTPN22-deficient mice of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. This could explain the lack of association of certain autoimmune conditions with PTPN22 risk alleles.

subject areas

  • Animals
  • Encephalomyelitis, Autoimmune, Experimental
  • Female
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Multiple Sclerosis
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22
  • T-Lymphocytes, Regulatory
  • Thymus Gland
  • Up-Regulation
scroll to property group menus

Identity

PubMed Central ID

  • PMC3358490

International Standard Serial Number (ISSN)

  • 0022-1767

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.1200150

PubMed ID

  • 22539785
scroll to property group menus

Additional Document Info

start page

  • 5267

end page

  • 5275

volume

  • 188

issue

  • 11

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support