Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Duncan, Katharine, Ph.D. in Chemistry, Scripps Research 2008 - 2014

authors

  • Leggans, E. K.
  • Barker, T. J.
  • Duncan, Katharine
  • Boger, Dale

publication date

  • March 2012

journal

  • Organic Letters  Journal

abstract

  • An Fe(III)/NaBH(4)-mediated reaction for the functionalization of unactivated alkenes is described defining the alkene substrate scope, establishing the exclusive Markovnikov addition, exploring a range of free radical traps, examining the Fe(III) salt and initiating hydride source, introducing H(2)O-cosolvent mixtures, and exploring catalytic variants. Its use led to the preparation of a novel, potent, and previously inaccessible C20'-vinblastine analogue.

subject areas

  • Alkenes
  • Borohydrides
  • Catalysis
  • Ferric Compounds
  • Molecular Structure
  • Vinblastine
scroll to property group menus

Identity

PubMed Central ID

  • PMC3306530

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol300173v

PubMed ID

  • 22369097
scroll to property group menus

Additional Document Info

start page

  • 1428

end page

  • 1431

volume

  • 14

issue

  • 6

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support