recent publications

• academic article

  • Kitagawa, T., Iwazawa, T., Robbins, P. D., Lotze, M. T., Tahara, H. Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models Journal of Gene Medicine  2003 5:958-965  DOI:10.1002/jgm.441  PMID:14601133
  • Nishioka, Y., Wen, H., Mitani, K., Robbins, P. D., Lotze, M. T., Sone, S., Tahara, H. Differential effects of il-12 on the generation of alloreactive ctl mediated by murine and human dendritic cells: A critical role for nitric oxide Journal of Leukocyte Biology  2003 73:621-629  DOI:10.1189/jlb.0402205  PMID:12714577
  • Numasaki, M., Fukushi, J., Ono, M., Narula, S. K., Zavodny, P. J., Kudo, T., Robbins, P. D., Tahara, H., Lotze, M. T. Interleukin-17 promotes angiogenesis and tumor growth Blood  2003 101:2620-2627  DOI:10.1182/blood-2002-05-1461  PMID:12411307
  • Hashimoto, W., Tanaka, F., Robbins, P. D., Taniguchi, M., Okamura, H., Lotze, M. T., Tahara, H. Natural killer, but not natural killer T, cells play a necessary role in the promotion of an innate antitumor response induced by IL-18 International Journal of Cancer  2003 103:508-513  DOI:10.1002/ijc.10844  PMID:12478667
  • Tanaka, F., Hashimoto, W., Robbins, P. D., Lotze, M. T., Tahara, H. Therapeutic and specific antitumor immunity induced by co-administration of immature dendritic cells and adenoviral vector expressing biologically active IL-18 Gene Therapy  2002 9:1480-1486  DOI:10.1038/sj.gt.3301827  PMID:12378411
  • Kang, W. K., Park, C., Yoon, H. L., Kim, W. S., Yoon, S. S., Lee, M. H., Park, K., Kim, K., Jeong, H. S., Kim, J. A., Nam, S. J., Yang, J. H., et al. Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: Outcome of a phase I study Human Gene Therapy  2001 12:671-684  DOI:10.1089/104303401300057388  PMID:11426466
  • Iwazawa, T., Chau, G. Y., Mori, T., Dookeran, K. A., Rubin, J. T., Watkins, S., Robbins, P. D., Lotze, M. T., Tahara, H. Potent antitumor effects of intra-arterial injection of fibroblasts genetically engineered to express IL-12 in liver metastasis model of rat: No additional benefit of using retroviral producer cell Cancer Gene Therapy  2001 8:17-22  PMID:11219489
  • Tanaka, F., Hashimoto, W., Okamura, H., Robbins, P. D., Lotze, M. T., Tahara, H. Rapid generation of potent and tumor-specific cytotoxic T lymphocytes by interleukin 18 using dendritic cells and natural killer cells Cancer Research  2000 60:4838-4844  PMID:10987295
  • Takayama, T., Morelli, A. E., Robbins, P. D., Tahara, H., Thomson, A. W. Feasibility of ctla4lg gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific t cell anergy in vitro Gene Therapy  2000 7:1265-1273  DOI:10.1038/sj.gt.3301244  PMID:10918497
  • Hirao, M., Onai, N., Hiroishi, K., Watkins, S. C., Matsushima, K., Robbins, P. D., Lotze, M. T., Tahara, H. Cc chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes Cancer Research  2000 60:2209-2217  PMID:10786686
  • Lotze, M. T., Shurin, M., Esche, C., Tahara, H., Storkus, W., Kirkwood, J. M., Whiteside, T. L., Elder, E. M., Okada, H., Robbins, P. Interleukin-2: Developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity Cancer Journal from Scientific American  2000 6:S61-S66  PMID:10685662
  • Nishioka, Y., Hirao, M., Robbins, P. D., Lotze, M. T., Tahara, H. Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12 Cancer Research  1999 59:4035-4041  PMID:10463604
  • Hashimoto, W., Osaki, T., Okamura, H., Robbins, P. D., Kurimoto, M., Nagata, S., Lotze, M. T., Tahara, H. Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively Journal of Immunology  1999 163:583-589  PMID:10395644
  • Osaki, T., Hashimoto, W., Gambotto, A., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., Tahara, H. Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18) Gene Therapy  1999 6:808-815  DOI:10.1038/sj.gt.3300908  PMID:10505105
  • Gambotto, A., Tuting, T., McVey, D. L., Kovesdi, I., Tahara, H., Lotze, M. T., Robbins, P. D. Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12 Cancer Gene Therapy  1999 6:45-53  DOI:10.1038/sj.cgt.7700013  PMID:10078963
  • Couderc, B., Zitvogel, L., Douin-Echinard, V., Djennane, L., Tahara, H., Favre, G., Lotze, M. T., Robbins, P. D. Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells Cancer Gene Therapy  1998 5:163-175  PMID:9622100
  • Osaki, T., Peron, J. M., Cai, Q. A., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., Tahara, H. Ifn-gamma-inducing factor il-18 administration mediates ifn-gamma- and il-12-independent antitumor effects Journal of Immunology  1998 160:1742-1749  PMID:9469432
  • Robbins, P. D., Tahara, H., Ghivizzani, S. C. Viral vectors for gene therapy Trends in Biotechnology  1998 16:35-40  DOI:10.1016/s0167-7799(97)01137-2  PMID:9470229
  • Tuting, T., Gambotto, A., Baar, J., Davis, I. D., Storkus, W. J., Zavodny, P. J., Narula, S., Tahara, H., Robbins, P. D., Lotze, M. T. Interferon-alpha gene therapy for cancer: Retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models Gene Therapy  1997 4:1053-1060  DOI:10.1038/sj.gt.3300509  PMID:9415311
  • Kim, S. H., An, C. S., Tahara, H., Park, C., Lotze, M. T., Robbins, P. D., Kim, S. Retroviral-mediated IL-12 gene therapy for advanced murine tumors Experimental and Molecular Medicine  1997 29:53-58  DOI:10.1038/emm.1997.8
  • Berman, R. M., Suzuki, T., Tahara, H., Robbins, P. D., Narula, S. K., Lotze, M. T. Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice Journal of Immunology  1996 157:231-238  PMID:8683120
  • Zitvogel, L., Robbins, P. D., Storkus, W. J., Clarke, M. R., Maeurer, M. J., Campbell, R. L., Davis, C. G., Tahara, H., Schreiber, R. D., Lotze, M. T. Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors European Journal of Immunology  1996 26:1335-1341  DOI:10.1002/eji.1830260624  PMID:8647214
  • Qin, L. H., Chavin, K. D., Ding, Y. Z., Tahara, H., Favaro, J. P., Woodward, J. E., Suzuki, T., Robbins, P. D., Lotze, M. T., Bromberg, J. S. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival Journal of Immunology  1996 156:2316-2323  PMID:8690923
  • Lotze, M. T., Zitvogel, L., Campbell, R., Robbins, P. D., Elder, E., Haluszczak, C., Martin, D., Whiteside, T. L., Storkus, W. J., Tahara, H. Cytokine gene therapy of cancer using interleukin-12: murine and clinical trials Annals of the New York Academy of Sciences  1996 795:440-454  DOI:10.1111/j.1749-6632.1996.tb52715.x  PMID:8958977
  • Tahara, H., Zitvogel, L., Storkus, W. J., Robbins, P. D., Lotze, M. T. Murine models of cancer cytokine gene therapy using interleukin-12 Annals of the New York Academy of Sciences  1996 795:275-283  DOI:10.1111/j.1749-6632.1996.tb52677.x  PMID:8958939
  • Tahara, H., Lotze, M., Robbins, P. D., Storkus, W. J., Zitvogel, L. IL-12 gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts Human Gene Therapy  1995 6:1607-1624  DOI:10.1089/hum.1995.6.12-1607  PMID:8664385
  • Zitvogel, L., Tahara, H., Robbins, P. D., Storkus, W. J., Clarke, M. R., Nalesnik, M. A., Lotze, M. T. Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts Journal of Immunology  1995 155:1393-1403  PMID:7636204
  • Suzuki, T., Tahara, H., Narula, S., Moore, K. W., Robbins, P. D., Lotze, M. T. Viral interleukin-10 (IL-10), the human herpes-virus-4 cellular IL-10 homolog, induces local anergy to allogeneic and syngeneic tumors Journal of Experimental Medicine  1995 182:477-486  DOI:10.1084/jem.182.2.477  PMID:7629507
  • Tahara, H., Zitvogel, L., Storkus, W. J., Zeh, H. J., McKinney, T. G., Schreiber, R. D., Gubler, U., Robbins, P. D., Lotze, M. T. Effective eradication of established murine tumors with IL-12 gene-therapy using a polycistronic retroviral vector Journal of Immunology  1995 154:6466-6474  PMID:7759882
  • Pappo, I., Tahara, H., Robbins, P. D., Gately, M. K., Wolf, S. F., Barnea, A., Lotze, M. T. Administration of systemic or local interleukin-2 enhances the antitumor effects of interleukin-12 gene-therapy Journal of Surgical Research  1995 58:218-226  DOI:10.1006/jsre.1995.1034  PMID:7861776
  • Zitvogel, L., Tahara, H., Cai, Q., Storkus, W. J., Muller, G., Wolf, S. F., Gately, M., Robbins, P. D., Lotze, M. T. Construction and characterization of retroviral vectors expressing biologically active human interleukin-12 Human Gene Therapy  1994 5:1493-1506  DOI:10.1089/hum.1994.5.12-1493  PMID:7711142
  • Tahara, H., Zeh, H. J., Storkus, W. J., Pappo, I., Watkins, S. C., Gubler, U., Wolf, S. F., Robbins, P. D., Lotze, M. T. Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo Cancer Research  1994 54:182-189  PMID:7903204
  • Robbins, P. D., Tahara, H., Mueller, G., Hung, G., Bahnson, A., Zitvogel, L., Galealauri, J., Ohashi, T., Patrene, K., Boggs, S. S., Evans, C. H., Barranger, J. A., et al. Retroviral vectors for use in human gene-therapy for cancer Gaucher disease, and arthritis Annals of the New York Academy of Sciences  1994 716:72-89  DOI:10.1111/j.1749-6632.1994.tb21704.x  PMID:7912915
  • Tahara, H., Mueller, G. M., Ricordi, C., Robbins, P. D., Lotze, M. T. Islet cell transplantation facilitated by gene-transfer Transplantation Proceedings  1992 24:2975-2976  PMID:1466019