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An activated protein c analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents

Academic Article
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Overview

authors

  • Wang, Y. M.
  • Zhang, Z. G.
  • Chow, N.
  • Davis, T. P.
  • Griffin, John
  • Chopp, M.
  • Zlokovic, B. V.

publication date

  • September 2012

journal

  • Stroke  Journal

subject areas

  • Animals
  • Anticoagulants
  • Brain
  • Brain Ischemia
  • Cerebral Hemorrhage
  • Fibrinolytic Agents
  • Hemoglobins
  • Infarction, Middle Cerebral Artery
  • Intracranial Embolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neurologic Examination
  • Protein C
  • Rats
  • Rats, Wistar
  • Stroke
  • Tissue Plasminogen Activator
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Research

keywords

  • ischemic stroke
  • neuroprotection
  • proteases
  • thrombolytic therapy
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Identity

PubMed Central ID

  • PMC3429704

International Standard Serial Number (ISSN)

  • 0039-2499

Digital Object Identifier (DOI)

  • 10.1161/strokeaha.112.658997

PubMed ID

  • 22811462
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Additional Document Info

start page

  • 2444

end page

  • 2449

volume

  • 43

issue

  • 9

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