Assembly of spirooxindole derivatives containing four consecutive stereocenters via organocatalytic michael-henry cascade reactions

Academic Article
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publication date

  • April 2012

abstract

  • A novel organocatalytic strategy for the synthesis of highly substituted spirocyclopentaneoxindoles was developed employing simple nitrostyrenes and 3-substituted oxindoles as starting materials. Michael-Henry cascade reactions, enabled through cinchona alkaloid organocatalysis, provided products in high yield and excellent enantioselectivity in a single step.