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A search for association between schizophrenia and dopamine-related alleles

Academic Article
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Overview

authors

  • Jonsson, E.
  • Brene, S.
  • Geijer, T.
  • Terenius, Lars
  • Tylec, A.
  • Persson, M. L.
  • Sedvall, G.

publication date

  • October 1996

journal

  • European Archives of Psychiatry and Clinical Neuroscience  Journal

abstract

  • Dopamine receptor dysfunction and altered tyrosine hydroxylase activity have both been implicated in the pathophysiology of schizophrenia. Schizophrenic patients and control subjects were examined for allele frequencies in the tyrosine hydroxylase and dopamine D2 and D4 receptor genes. No significant differences of allele or genotype frequencies were found between the two groups after adjustment for multiple comparisons. Neither were any significant relationships observed between allele frequencies and a number of clinical variables within the schizophrenic subsample. When no adjustment was made for multiple testing a few significant tendencies were obtained which warrant further research in extended patient and control materials. The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.

subject areas

  • Adult
  • Aged
  • Alleles
  • Brain
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Receptors, Dopamine D2
  • Schizophrenia
  • Tyrosine 3-Monooxygenase
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Research

keywords

  • association study
  • dopamine receptors (DRD2, DRD4)
  • schizophrenia
  • tyrosine hydroxylase
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Identity

International Standard Serial Number (ISSN)

  • 0940-1334

Digital Object Identifier (DOI)

  • 10.1007/bf02189022

PubMed ID

  • 8908411
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Additional Document Info

start page

  • 297

end page

  • 304

volume

  • 246

issue

  • 6

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