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Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

Academic Article
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Overview

authors

  • Parolin, C.
  • Borsetti, A.
  • Choe, Hyeryun
  • Farzan, Michael
  • Kolchinsky, P.
  • Heesen, M.
  • Ma, Q.
  • Gerard, C.
  • Palu, G.
  • Dorf, M. E.
  • Springer, T.
  • Sodroski, J.

publication date

  • 1998

journal

  • Journal of Virology  Journal

abstract

  • The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

subject areas

  • Animals
  • HIV-1
  • Humans
  • Mice
  • Receptors, CCR4
  • Receptors, Chemokine
  • Receptors, Virus
  • T-Lymphocytes
  • Virus Replication
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Identity

PubMed Central ID

  • PMC124650

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 9445072
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Additional Document Info

start page

  • 1652

end page

  • 1656

volume

  • 72

issue

  • 2

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