Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

The striatonigral dynorphin pathway of the rat studied with in vivo microdialysis: II. Effects of dopamine D1 and D2 receptor agonists

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • You, Z. B.
  • Herrera-Marschitz, M.
  • Nylander, I.
  • Goiny, M.
  • Oconnor, W. T.
  • Ungerstedt, U.
  • Terenius, Lars

publication date

  • 1994

journal

  • Neuroscience  Journal

abstract

  • In vivo microdialysis was used to study the effect of intracerebral administration of dopamine agonists on dynorphin B release in the striatum and substantia nigra of rats. The release of dopamine and GABA was also investigated. Administration of the dopamine D1 agonist SKF 38393 (10-100 microM) into the striatum increased extracellular dynorphin B and GABA levels in the ipsilateral substantia nigra, in a concentration-dependent manner. After a short-lasting increase, nigral dopamine levels were significantly decreased after the highest concentration of striatal SKF 38393. An increase in striatal dynorphin B, GABA and dopamine levels was also observed. When SKF 38393 (10 microM) was administered into the substantia nigra, nigral dynorphin B and GABA, but not dopamine levels increased. No significant effects were observed on striatal levels. Administration of the dopamine D2 agonist, quinpirole (100 microM), into the striatum decreased dopamine levels in both striatum and substantia nigra, while no effect was observed on striatal or nigral dynorphin B and GABA levels. Quinpirole (10-100 microM) given into the substantia nigra, decreased striatal dopamine levels in a concentration manner. In the nigra, a short-lasting increase in dopamine levels was observed following the highest concentration of nigral quinpirole (100 microM). The effect was followed by a decrease in dopamine levels. No significant effects were observed on striatal or nigral dynorphin B and GABA levels. The results show that stimulation of D1 receptors in striatum and substantia nigra leads to activation of the striatonigral dynorphin pathway. A parallel effect could also be seen on nigral GABA release.(ABSTRACT TRUNCATED AT 250 WORDS)

subject areas

  • Animals
  • Corpus Striatum
  • Dopamine
  • Dynorphins
  • Endorphins
  • Male
  • Microdialysis
  • Neural Pathways
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Substantia Nigra
  • gamma-Aminobutyric Acid
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0306-4522

Digital Object Identifier (DOI)

  • 10.1016/0306-4522(94)90540-1

PubMed ID

  • 7891856
scroll to property group menus

Additional Document Info

start page

  • 427

end page

  • 434

volume

  • 63

issue

  • 2

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support