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ERK and cell death: ERK1/2 in neuronal death

Academic Article
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Overview

authors

  • Subramaniam, Srinivasa
  • Unsicker, K.

publication date

  • 2010

journal

  • FEBS Journal  Journal

abstract

  • Extracellular signal-regulated kinase (ERK) is a versatile protein kinase that regulates many cellular functions. Growing evidence suggests that ERK1/2 plays a crucial role in promoting cell death in a variety of neuronal systems, including neurodegenerative diseases. It is believed that the magnitude and the duration of ERK1/2 activity determine its cellular function. In this review, we summarize recent evidence for a role of ERK1/2 in neuronal death. Furthermore, we discuss the mechanisms involved in ERK1/2 mediating neuronal death.

subject areas

  • Animals
  • Cell Death
  • Extracellular Signal-Regulated MAP Kinases
  • Humans
  • Ischemia
  • MAP Kinase Signaling System
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • Models, Neurological
  • Nerve Degeneration
  • Neurodegenerative Diseases
  • Neurons
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Research

keywords

  • Akt
  • ERK
  • PKB
  • apoptosis
  • caspase
  • cell survival
  • ischemia
  • neurodegenerative disease
  • neuronal death
  • sustained ERK
  • transient ERK
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Identity

International Standard Serial Number (ISSN)

  • 1742-464X

Digital Object Identifier (DOI)

  • 10.1111/j.1742-4658.2009.07367.x

PubMed ID

  • 19843173
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Additional Document Info

start page

  • 22

end page

  • 29

volume

  • 277

issue

  • 1

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