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Anti-IFN-alpha/beta receptor antibody treatment ameliorates disease in lupus-predisposed mice

Academic Article
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Overview

authors

  • Baccalà, Roberto
  • Gonzalez-Quintial, R.
  • Schreiber, R. D.
  • Lawson, Brian
  • Kono, Dwight
  • Theofilopoulos, Argyrios

publication date

  • 2012

journal

  • Journal of Immunology  Journal

abstract

  • The demonstration in humans and mice that nucleic acid-sensing TLRs and type I IFNs are essential disease mediators is a milestone in delineating the mechanisms of lupus pathogenesis. In this study, we show that Ifnb gene deletion does not modify disease progression in NZB mice, thereby strongly implicating IFN-α subtypes as the principal pathogenic effectors. We further document that long-term treatment of male BXSB mice with an anti-IFN-α/β receptor Ab of mouse origin reduced serologic, cellular, and histologic disease manifestations and extended survival, suggesting that disease acceleration by the Tlr7 gene duplication in this model is mediated by type I IFN signaling. The efficacy of this treatment in BXSB mice was clearly evident when applied early in the disease process, but only partial reductions in some disease characteristics were observed when treatment was initiated at later stages. A transient therapeutic effect was also noted in the MRL-Fas(lpr) model, although overall mortality was unaffected. The combined findings suggest that IFN-α/β receptor blockade, particularly when started at early disease stages, may be a useful treatment approach for human systemic lupus erythematosus and other autoimmune syndromes.

subject areas

  • Animals
  • Antibodies, Antinuclear
  • Antibodies, Monoclonal
  • Autoantibodies
  • Cells, Cultured
  • Genetic Predisposition to Disease
  • Humans
  • Lupus Nephritis
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred MRL lpr
  • Mice, Inbred NZB
  • Mice, Knockout
  • Proteinuria
  • Receptor, Interferon alpha-beta
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Identity

PubMed Central ID

  • PMC3530925

International Standard Serial Number (ISSN)

  • 0022-1767

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.1201477

PubMed ID

  • 23175700
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Additional Document Info

start page

  • 5976

end page

  • 5984

volume

  • 189

issue

  • 12

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