Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

The nociceptin system and hippocampal cognition in mice a pharmacological and genetic analysis

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Kuzmin, A.
  • Madjid, N.
  • Johansson, B.
  • Terenius, Lars
  • Ogren, S. O.

publication date

  • December 2009

journal

  • Brain Research  Journal

abstract

  • This study examines the effects of NOP agonists nociceptin/orphanin FQ (N/OFQ) and Ro 64-6198, NOP antagonists [Nphe(1)]N/OFQ(1-13)-NH(2) Nphe(1) and naloxone benzoylhydrazone (NalBzoH) on spatial memory in NMRI mice and pronociceptin (proNC) knockout (KO) mice using the water maze task. N/OFQ, administered i.c.v. (1, 5 and 10 nmol/mouse) and into hippocampal CA3 (1 nmol/mouse, bilaterally), impaired acquisition and retention in the maze. Impairments were blocked by pre-treatment with Nphe(1) (10 nmol, i.c.v.). Ro 64-6198 (0.1-0.3-1 mg/kg i.p.) also dose-dependently impaired learning. However, pre-treatment with NalBzoH (1 mg/kg, s.c.) failed to modify the effects of Ro 64-6198. Nphe(1) (10 nmol/mouse i.c.v.) and NalBzoH (1 mg/kg, s.c.) by themselves failed to affect maze performance, despite a tendency for enhanced performance. Prepro N/OFQ knockout (ppN/OFQ -/-) showed evidence of improved learning, evident at retention trials and in reversal training. ppN/OFQ -/- mice were not impaired by N/OFQ (10 nmol i.c.v.) in the task, suggesting that changes in postsynaptic NOP receptors may occur in such KO mice. It is concluded that N/OFQ and NOP receptors have an important role in hippocampus-dependent spatial learning and memory, probably by modulation of glutamatergic functions.

subject areas

  • Animals
  • Central Nervous System Agents
  • Cognition
  • Dose-Response Relationship, Drug
  • Hippocampus
  • Imidazoles
  • Male
  • Maze Learning
  • Memory
  • Mice
  • Mice, Inbred Strains
  • Mice, Knockout
  • Naloxone
  • Narcotic Antagonists
  • Neuropsychological Tests
  • Opioid Peptides
  • Peptide Fragments
  • Protein Precursors
  • Random Allocation
  • Receptors, Opioid
  • Reversal Learning
  • Spiro Compounds
  • Time Factors
scroll to property group menus

Research

keywords

  • Learning and memory
  • Mice
  • NOP receptor
  • Nociceptin
  • Ro 64-6198
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/j.brainres.2009.09.075

PubMed ID

  • 19782658
scroll to property group menus

Additional Document Info

start page

  • S7

end page

  • S19

volume

  • 1305

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support