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Effect of low-frequency and high-frequency tens on met-enkephalin-arg-phe and dynorphin-a immunoreactivity in human lumbar csf

Academic Article
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Overview

authors

  • Han, J. S.
  • Chen, X. H.
  • Sun, S. L.
  • Xu, X. J.
  • Yuan, Y.
  • Yan, S. C.
  • Hao, J. X.
  • Terenius, Lars

publication date

  • December 1991

journal

  • Pain  Journal

abstract

  • Transcutaneous nerve stimulation (TENS) treatment was given for 30 min to 37 patients divided into 3 groups of 10 patients and 1 group of 7 patients. Two groups received low-frequency (2 Hz) and the other 2 groups high-frequency (100 Hz) stimulation. A diagnostic lumbar cerebrospinal fluid (CSF) sample was obtained immediately before and after stimulation. The CSF samples were subjected to analysis of immunoreactive (ir) opioid peptides, Met-enkephalin-Arg-Phe (MEAP) from preproenkephalin and dynorphin A (Dyn A) from preprodynorphin, respectively. Low frequency TENS applied on the hand and the leg resulted in a marked increase (367%, P less than 0.05) of ir-MEAP but not ir-Dyn A, whereas high-frequency (100 Hz) TENS produced a 49% increase in ir-Dyn A (P less than 0.01) but not ir-MEAP. This is the first report in humans that 2 Hz and 100 Hz peripheral stimulation induces differential release of peptides from preproenkephalin and preprodynorphin, respectively.

subject areas

  • Adult
  • Dynorphins
  • Electroacupuncture
  • Enkephalin, Methionine
  • Humans
  • Middle Aged
  • Radioimmunoassay
  • Transcutaneous Electric Nerve Stimulation
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Research

keywords

  • (HUMAN)
  • DYNORPHIN-A
  • ELECTROACUPUNCTURE
  • MET-ENKEPHALIN-ARG-PHE
  • OPIOID PEPTIDE
  • TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION (TENS)
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Identity

International Standard Serial Number (ISSN)

  • 0304-3959

Digital Object Identifier (DOI)

  • 10.1016/0304-3959(91)90218-m

PubMed ID

  • 1686080
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Additional Document Info

start page

  • 295

end page

  • 298

volume

  • 47

issue

  • 3

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