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Proteinergic profiles in cerebrospinal-fluid from alcoholic subjects

Academic Article
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Overview

authors

  • Silberring, J.
  • Brostedt, P.
  • Neiman, J.
  • Hellman, U.
  • Liljequist, S.
  • Terenius, Lars

publication date

  • 1994

journal

  • Biomedical Chromatography  Journal

abstract

  • Minute amounts of cerebrospinal fluid samples from alcoholics were subjected to separation by HPLC-molecular sieving, combined with multispectral UV analysis of the acquired data. A significant difference in the protein/polypeptide pattern within the molecular weight range of 7-10 kDa has been observed between samples, taken directly after detoxification and 2 weeks later. Spectral analysis of the results suggests that the components are of peptidergic nature. On the other hand, albumin content did not differ significantly, suggesting that the blood-brain barrier was not affected. An enzyme marker, dynorphin converting enzyme, remained unchanged in both groups.

subject areas

  • Adult
  • Aged
  • Albumins
  • Alcoholism
  • Cerebrospinal Fluid Proteins
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Cystatin C
  • Cystatins
  • Humans
  • Intracranial Pressure
  • Male
  • Middle Aged
  • Molecular Weight
  • Spectrophotometry, Ultraviolet
  • beta 2-Microglobulin
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Identity

International Standard Serial Number (ISSN)

  • 0269-3879

Digital Object Identifier (DOI)

  • 10.1002/bmc.1130080309

PubMed ID

  • 8075523
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Additional Document Info

start page

  • 137

end page

  • 141

volume

  • 8

issue

  • 3

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