recent publications

• academic article

  • Sun, Y., Liu, C. H., SanGiovanni, J. P., Evans, L. P., Tian, K. T., Zhang, B., Stahl, A., Pu, W. T., Kamenecka, T. M., Solt, L. A., Chen, J. Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation Proceedings of the National Academy of Sciences of the United States of America  2015 112:10401-10406  DOI:10.1073/pnas.1504387112  PMID:26243880  PMCID:PMC4547221
  • Cao, Y., Axup, J. Y., Ma, J. S. Y., Wang, R. E., Choi, S., Tardif, V., Lim, R. K. V., Pugh, H. M., Lawson, B. R., Welzel, G., Kazane, S. A., Sun, Y., et al. Multiformat T-cell-engaging bispecific antibodies targeting human breast cancers Angewandte Chemie-International Edition  2015 54:7022-7027  DOI:10.1002/anie.201500799  PMID:25919418  PMCID:PMC4492699
  • Delhanty, P. J. D., van der Velde, M., van der Eerden, B. C. J., Sun, Y., Geminn, J. M. M., van der Lely, A. J., Smith, R. G., van Leeuwen, J. P. T. M. Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling Endocrinology  2014 155:4287-4295  DOI:10.1210/en.2013-2055  PMID:25060361
  • Kularatne, S. A., Deshmukh, V., Ma, J., Tardif, V., Lim, R. K. V., Pugh, H. M., Sun, Y., Manibusan, A., Sellers, A. J., Barnett, R. S., Srinagesh, S., Forsyth, J. S., et al. A CXCR4-targeted site-specific antibody-drug conjugate Angewandte Chemie-International Edition  2014 53:11863-11867  DOI:10.1002/anie.201408103  PMID:25213874  PMCID:PMC4331128
  • Tian, F., Lu, Y., Manibusan, A., Sellers, A., Tran, H., Sun, Y., Phuong, T., Barnett, R., Hehli, B., Song, F., DeGuzman, M. J., Ensari, S., et al. A general approach to site-specific antibody drug conjugates Proceedings of the National Academy of Sciences of the United States of America  2014 111:1766-1771  DOI:10.1073/pnas.1321237111  PMID:24443552  PMCID:PMC3918752
  • Kularatne, S. A., Deshmukh, V., Gymnopoulos, M., Biroc, S. L., Xia, J. M., Srinagesh, S., Sun, Y., Zou, N., Shimazu, M., Pinkstaff, J., Ensari, S., Knudsen, N., et al. Recruiting cytotoxic T cells to folate-receptor-positive cancer cells Angewandte Chemie-International Edition  2013 52:12101-12104  DOI:10.1002/anie.201306866  PMID:24573789  PMCID:PMC4012751
  • Bian, M., Wang, Z., Xiong, X. C., Sun, Y., Matera, C., Nicolaou, K. C., Li, A. Total syntheses of anominine and tubingensin a Journal of the American Chemical Society  2012 134:8078-8081  DOI:10.1021/ja302765m  PMID:22537293
  • Singleton, K. L., Roybal, K. T., Sun, Y., Fu, G., Gascoigne, N. R. J., van Oers, N. S. C., Wulfing, C. Spatiotemporal patterning during t cell activation is highly diverse Science Signaling  2009 2:ra15  DOI:10.1126/scisignal.2000199  PMID:19351954  PMCID:PMC2694444
  • Lee, C. W., Kim, N. H., Choi, H. K., Sun, Y., Nam, J. S., Rhee, H. J., Chun, J., Huh, S. O. Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated by mitogen- and stress-activated protein kinase-1 Journal of Cellular Biochemistry  2008 104:785-794  DOI:10.1002/jcb.21663  PMID:18172855
  • Smith, R. G., Sun, Y., Jiang, H., Albarran-Zeckler, R., Timchenko, N. Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging Annals of the New York Academy of Sciences  2007 1119:147-164  DOI:10.1196/annals.1404.023  PMID:18056963
  • Letvin, N. L., Mascola, J. R., Sun, Y., Gorgone, D. A., Buzby, A. P., Xu, L., Yang, Z. Y., Chakrabarti, B., Rao, S. S., Schmitz, J. E., Montefiori, D. C., Barker, B. R., et al. Preserved cd4(+) central memory t cells and survival in vaccinated siv-challenged monkeys Science  2006 312:1530-1533  DOI:10.1126/science.1124226  PMID:16763152  PMCID:PMC2365913
  • Li, H., Liu, Y., Shin, S., Sun, Y., Loring, J. F., Mattson, M. P., Rao, M. S., Zhan, M. Transcriptome coexpression map of human embryonic stem cells BMC Genomics  2006 7:103  DOI:10.1186/1471-2164-7-103  PMID:16670017  PMCID:PMC1523211
  • Sun, Y., Asnicar, M., Saha, P. K., Chan, L., Smith, R. G. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice Cell Metabolism  2006 3:379-386  DOI:10.1016/j.cmet.2006.04.004  PMID:16679295
  • Farzan, M., Choe, H., Desjardins, E., Sun, Y., Kuhn, J., Cao, J., Archambault, D., Kolchinsky, P., Koch, M., Wyatt, R., Sodroski, J. Stabilization of human immunodeficiency virus type 1 envelope glycoprotein trimers by disulfide bonds introduced into the gp41 glycoprotein ectodomain Journal of Virology  1998 72:7620-7625  PMID:9696864  PMCID:PMC110020
  • Sullivan, N., Sun, Y., Binley, J., Lee, J., Barbas, C. F., Parren, Pwhi, Burton, D. R., Sodroski, J. Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble cd4 and monoclonal antibodies Journal of Virology  1998 72:6332-6338  PMID:9658072  PMCID:PMC109776
  • Choe, H., Farzan, M., Konkel, M., Martin, K., Sun, Y., Marcon, L., Cayabyab, M., Berman, M., Dorf, M. E., Gerard, N., Gerard, C., Sodroski, J. The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1 Journal of Virology  1998 72:6113-6118  PMID:9621075  PMCID:PMC110417
  • Rizzuto, C. D., Wyatt, R., Hernandez-Ramos, N., Sun, Y., Kwong, P. D., Hendrickson, W. A., Sodroski, J. A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding Science  1998 280:1949-1953  DOI:10.1126/science.280.5371.1949  PMID:9632396
  • Farzan, M., Choe, H., Vaca, L., Martin, K., Sun, Y., Desjardins, E., Ruffing, N., Wu, L. J., Wyatt, R., Gerard, N., Gerard, C., Sodroski, J. A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5 Journal of Virology  1998 72:1160-1164  PMID:9445013  PMCID:PMC124591
  • Farzan, M., Choe, H., Martin, K., Marcon, L., Hofmann, W., Karlsson, G., Sun, Y., Barrett, P., Marchand, N., Sullivan, N., Gerard, N., Gerard, C., et al. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection Journal of Experimental Medicine  1997 186:405-411  DOI:10.1084/jem.186.3.405  PMID:9236192  PMCID:PMC2198994
  • Farzan, M., Choe, H., Martin, K. A., Sun, Y., Sidelko, M., Mackay, C. R., Gerard, N. P., Sodroski, J., Gerard, C. HIV-1 entry and macrophage inflammatory protein-1 beta-mediated signaling are independent functions of the chemokine receptor CCR5 Journal of Biological Chemistry  1997 272:6854-6857  PMID:9054370
  • Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., Wu, L. J., Mackay, C. R., LaRosa, G., Newman, W., Gerard, N., Gerard, C., et al. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates Cell  1996 85:1135-1148  DOI:10.1016/s0092-8674(00)81313-6  PMID:8674119