recent publications

• academic article

  • Zarpellon, A., Celikel, R., Roberts, J. R., McClintock, R. A., Mendolicchio, G. L., Moore, K. L., Jing, H., Varughese, K. I., Ruggeri, Z. M. Binding of α-thrombin to surface-anchored platelet glycoprotein Ibα sulfotyrosines through a two-site mechanism involving exosite I Proceedings of the National Academy of Sciences of the United States of America  2011 108:8628-8633  DOI:10.1073/pnas.1017042108  PMID:21555542  PMCID:PMC3102361
  • Ruggeri, Z. M., Zarpellon, A., Roberts, J. R., McClintock, R. A., Jing, H., Mendolicchio, G. L. Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb Thrombosis and Haemostasis  2010 104:894-902  DOI:10.1160/th10-09-0578  PMID:20941453  PMCID:PMC3810535
  • Celikel, R., McClintock, R. A., Roberts, J. R., Mendolicchio, G. L., Ware, J., Varughese, K. I., Ruggeri, Z. M. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha Science  2003 301:218-221  DOI:10.1126/science.1084183  PMID:12855810
  • Vasudevan, S., Roberts, J. R., McClintock, R. A., Dent, J. A., Celikel, R., Ware, J., Varughese, K. I., Ruggeri, Z. M. Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ib alpha Journal of Biological Chemistry  2000 275:12763-12768  DOI:10.1074/jbc.275.17.12763  PMID:10777573
  • Berliner, S., Niiya, K., Roberts, J. R., Houghten, R. A., Ruggeri, Z. M. Generation and characterization of peptide-specific antibodies that inhibit von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro1743 and other amino acid residues adjacent to the sequence Arg1744-Gly1745-Asp1746 Journal of Biological Chemistry  1988 263:7500-7505  PMID:2453507
  • Fujimura, Y., Titani, K., Holland, L. Z., Roberts, J. R., Kostel, P., Ruggeri, Z. M., Zimmerman, T. S. A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728 Journal of Biological Chemistry  1987 262:1734-1739  PMID:3100536
  • Handa, M., Titani, K., Holland, L. Z., Roberts, J. R., Ruggeri, Z. M. The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments Journal of Biological Chemistry  1986 261:2579-2585  PMID:2943738
  • Fujimura, Y., Titani, K., Holland, L. Z., Russell, S. R., Roberts, J. R., Elder, J. H., Ruggeri, Z. M., Zimmerman, T. S. von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib Journal of Biological Chemistry  1986 261:381-385  PMID:2934387
  • Lombardo, V. T., Hodson, E., Roberts, J. R., Kunicki, T. J., Zimmerman, T. S., Ruggeri, Z. M. Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody Journal of Clinical Investigation  1985 76:1950-1958  DOI:10.1172/jci112193  PMID:2414325  PMCID:PMC424250