recent publications

• academic article

  • Wang, C., Wu, H., Evron, T., Vardy, E., Han, G. W., Huang, X. P., Hufeisen, S. J., Mangano, T. J., Urban, D. J., Katritch, V., Cherezov, V., Caron, M. G., et al. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Nature Communications  2014 5:4355  DOI:10.1038/ncomms5355  PMID:25008467  PMCID:PMC4198951
  • Fenalti, G., Giguere, P. M., Katritch, V., Huang, X. P., Thompson, A. A., Cherezov, V., Roth, B. L., Stevens, R. C. Molecular control of delta-opioid receptor signalling Nature  2014 506:191-196  DOI:10.1038/nature12944  PMID:24413399  PMCID:PMC3931418
  • Wang, C., Wu, H., Katritch, V., Han, G. W., Huang, X. P., Liu, W., Siu, F. Y., Roth, B. L., Cherezov, V., Stevens, R. C. Structure of the human smoothened receptor bound to an antitumour agent Nature  2013 497:338-343  DOI:10.1038/nature12167  PMID:23636324  PMCID:PMC3657389
  • Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G. W., Liu, W., Huang, X. P., Vardy, E., McCorvy, J. D., Gao, X., et al. Structural basis for molecular recognition at serotonin receptors Science  2013 340:610-614  DOI:10.1126/science.1232807  PMID:23519210  PMCID:PMC3644373
  • Wacker, D., Wang, C., Katritch, V., Han, G. W., Huang, X. P., Vardy, E., McCorvy, J. D., Jiang, Y., Chu, M., Siu, F. Y., Liu, W., Xu, H. E., et al. Structural features for functional selectivity at serotonin receptors Science  2013 340:615-619  DOI:10.1126/science.1232808  PMID:23519215  PMCID:PMC3644390
  • Wu, H. X., Wacker, D., Mileni, M., Katritch, V., Han, G. W., Vardy, E., Liu, W., Thompson, A. A., Huang, X. P., Carroll, F. I., Mascarella, S. W., Westkaemper, R. B., et al. Structure of the human κ-opioid receptor in complex with JDTic Nature  2012 485:327-332  DOI:10.1038/nature10939  PMID:22437504  PMCID:PMC3356457
  • Thompson, A. A., Liu, W., Chun, E., Katritch, V., Wu, H. X., Vardy, E., Huang, X. P., Trapella, C., Guerrini, R., Calo, G., Roth, B. L., Cherezov, V., et al. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Nature  2012 485:395-399  DOI:10.1038/nature11085  PMID:22596163  PMCID:PMC3356928
  • Abbas, A. I., Hedlund, P. B., Huang, X. P., Tran, T. B., Meltzer, H. Y., Roth, B. L. Amisulpride is a potent 5-ht(7) antagonist: Relevance for antidepressant actions in vivo Psychopharmacology  2009 205:119-128  DOI:10.1007/s00213-009-1521-8  PMID:19337725  PMCID:PMC2821721