recent publications

• academic article

  • Li, L. S., Sinha, S. C. Studies toward the duocarmycin prodrugs for the antibody prodrug therapy approach Tetrahedron Letters  2009 50:2932-2935  DOI:10.1016/j.tetlet.2009.03.205  PMID:20160897  PMCID:PMC2768327
  • Abraham, S., Guo, F., Li, L. S., Rader, C., Liu, C., Barbas, C. F., 3rd, Lerner, R. A., Sinha, S. C. Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation Proceedings of the National Academy of Sciences of the United States of America  2007 104:5584-5589  DOI:10.1073/pnas.0700223104  PMID:17372220  PMCID:PMC1838444
  • Sinha, S. C., Das, S., Li, L. S., Lerner, R. A., Barbas, C. F. Preparation of integrin alpha(v) beta(3)-targeting ab 38c2 constructs Nature Protocols  2007 2:449-456  DOI:10.1038/nprot.2007.3  PMID:17406606
  • Li, L. S., Babendure, J. L., Sinha, S. C., Olefsky, J. M., Lerner, R. A. Synthesis and evaluation of photolabile insulin prodrugs Bioorganic & Medicinal Chemistry Letters  2005 15:3917-3920  DOI:10.1016/j.bmcl.2005.05.112  PMID:15993597
  • Das, S., Li, L. S., Abraham, S., Chen, Z. Y., Sinha, S. C. A bidirectional approach to the synthesis of a complete library of adjacent-bis-thf annonaceous acetogenins Journal of Organic Chemistry  2005 70:5922-5931  DOI:10.1021/jo050697c  PMID:16018687
  • Li, L. S., Rader, C., Matsushita, M., Das, S., Barbas, C. F., Lerner, R. A., Sinha, S. C. Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices Journal of Medicinal Chemistry  2004 47:5630-5640  DOI:10.1021/jm049666k  PMID:15509162
  • Sinha, S. C., Li, L. S., Watanabe, S., Kaltgrad, E., Tanaka, F., Rader, C., Lerner, R. A., Barbas, C. F. Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy Chemistry-a European Journal  2004 10:5467-5472  DOI:10.1002/chem.200400419  PMID:15378729
  • Sinha, S. C., Li, L. S., Miller, G. P., Dutta, S., Rader, C., Lerner, R. A. Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab Proceedings of the National Academy of Sciences of the United States of America  2004 101:3095-3099  DOI:10.1073/pnas.0307319101  PMID:14981258  PMCID:PMC365749
  • Li, L. S., Das, S., Sinha, S. C. Efficient one-step aldol-type reaction of ketones with acetals and ketals mediated by dibutylboron triflate/diisopropylethyl amine Organic Letters  2004 6:127-130  DOI:10.1021/ol030108u  PMID:14703367
  • Das, S., Li, L. S., Sinha, S. C. Stereloselective aldol-type cyclization reaction mediated by dibutylboron triflate/diisopropylethylamine Organic Letters  2004 6:123-126  DOI:10.1021/ol036229b  PMID:14703366