recent publications

• academic article

  • Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A., Joyce, M. G., Lingwood, D., Soto, C., Bailer, R. T., Ernandes, M. J., Kong, R., et al. Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors Cell  2015 161:1280-1292  DOI:10.1016/j.cell.2015.05.007  PMID:26004070  PMCID:PMC4683157
  • Shie, J. J., Fang, J. M., Lai, P. T., Wen, W. H., Wang, S. Y., Cheng, Y. S. E., Tsai, K. C., Yang, A. S., Wong, C. H. A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity Journal of the American Chemical Society  2011 133:17959-17965  DOI:10.1021/ja207892q  PMID:21942552
  • Shen, Y. F., Chen, Y. H., Chu, S. Y., Lin, M. I., Hsu, H. T., Wu, P. Y., Wu, C. J., Liu, H. W., Lin, F. Y., Lin, G., Hsu, P. H., Yang, A. S., et al. E339 ... R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors Proceedings of the National Academy of Sciences of the United States of America  2011 108:16515-16520  DOI:10.1073/pnas.1113107108  PMID:21930946  PMCID:PMC3189076
  • Wen, W. H., Wang, S. Y., Tsai, K. C., Cheng, Y. S. E., Yang, A. S., Fang, J. M., Wong, C. H. Analogs of zanamivir with modified c4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses Bioorganic & Medicinal Chemistry  2010 18:4074-4084  DOI:10.1016/j.bmc.2010.04.010  PMID:20452227
  • Shao, Y. M., Yang, W. B., Kuo, T. H., Tsai, K. C., Yang, A. S., Liang, P. H., Wong, C. H., Lin, C. H. Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease Bioorganic & Medicinal Chemistry  2008 16:4652-4660  DOI:10.1016/j.bmc.2008.02.040  PMID:18329272
  • Shie, J. J., Fang, J. M., Wang, S. Y., Tsai, K. C., Cheng, Y. S. E., Yang, A. S., Hsiao, S. C., Su, C. Y., Wong, C. H. Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity Journal of the American Chemical Society  2007 129:11892-11893  DOI:10.1021/ja073992i  PMID:17850083
  • Shao, Y. M., Yang, W. B., Peng, H. P., Hsu, M. F., Tsa, K. C., Kuo, T. H., Wang, A. H. J., Liang, P. H., Yang, A. S., Wong, C. H., Lin, C. H. Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors ChemBioChem  2007 8:1654-1657  DOI:10.1002/cbic.200700254  PMID:17722121