recent publications

• academic article

  • Ishikawa, T., Kono, D., Chung, J., Fowler, P., Theofilopoulos, A., Kakumu, S., Chisari, F. V. Polyclonality and multispecificity of the CTL response to a single viral epitope Journal of Immunology  1998 161:5842-5850  PMID:9834062
  • Shimizu, Y., Guidotti, L. G., Fowler, P., Chisari, F. V. Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice Journal of Immunology  1998 161:4520-4529  PMID:9794377
  • Nakamoto, Y., Guidotti, L. G., Kuhlen, C. V., Fowler, P., Chisari, F. V. Immune pathogenesis of hepatocellular carcinoma Journal of Experimental Medicine  1998 188:341-350  DOI:10.1084/jem.188.2.341  PMID:9670046
  • Bertoni, R., Sidney, J., Fowler, P., Chesnut, R. W., Chisari, F. V., Sette, A. Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis Journal of Clinical Investigation  1997 100:503-513  DOI:10.1172/jci119559  PMID:9239396
  • Tcheng, J. E., Lincoff, A. M., Sigmon, K. N., Lee, K. L., Kitt, M. M., Califf, R. M., Topol, E. J., Juran, N., Worley, S., Tuzi, J., Hollywood, L., Kleiman, N. S., et al. Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT II Lancet  1997 349:1422-1428  PMID:9164315
  • Rehermann, B., Fowler, P., Sidney, J., Person, J., Redeker, A., Brown, M., Moss, B., Sette, A., Chisari, F. V. The cytotoxic T-lymphocyte response to multiple hepatitis-B virus polymerase epitopes during and after acute viral-hepatitis Journal of Experimental Medicine  1995 181:1047-1058  DOI:10.1084/jem.181.3.1047  PMID:7532675
  • Cerny, A., McHutchison, J. G., Pasquinelli, C., Brown, M. E., Brothers, M. A., Grabscheid, B., Fowler, P., Houghton, M., Chisari, F. V. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif Journal of Clinical Investigation  1995 95:521-530  DOI:10.1172/jci117694  PMID:7860734  PMCID:PMC295505
  • Cerny, A., Fowler, P., Brothers, M. A., Houghton, M., Schlicht, H. J., Chisari, F. V. Induction in vitro of a primary human antiviral cytotoxic T cell response European Journal of Immunology  1995 25:627-630  DOI:10.1002/eji.1830250248  PMID:7875224
  • Hagen, T. M., Huang, S., Curnutte, J., Fowler, P., Martinez, V., Wehr, C. M., Ames, B. N., Chisari, F. V. Extensive oxidative DNA-damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular-carcinoma Proceedings of the National Academy of Sciences of the United States of America  1994 91:12808-12812  DOI:10.1073/pnas.91.26.12808  PMID:7809125
  • Sette, A., Vitiello, A., Reherman, B., Fowler, P., Nayersina, R., Kast, W. M., Melief, C. J. M., Oseroff, C., Yuan, L., Ruppert, J., Sidney, J., Delguercio, M. F., et al. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes Journal of Immunology  1994 153:5586-5592  PMID:7527444
  • Huang, J. H., Getty, R. R., Chisari, F. V., Fowler, P., Greenspan, N. S., Tykocinski, M. L. Protein transfer of preformed MHC-peptide complexes sensitizes target cells to T cell cytolysis Immunity  1994 1:607-613  DOI:10.1016/1074-7613(94)90050-7  PMID:7600289
  • Nayersina, R., Fowler, P., Guilhot, S., Missale, G., Cerny, A., Schlicht, H. J., Vitiello, A., Chesnut, R., Person, J. L., Redeker, A. G., Chisari, F. V. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection Journal of Immunology  1993 150:4659-4671  PMID:7683326
  • Bertoletti, A., Chisari, F. V., Penna, A., Guilhot, S., Galati, L., Missale, G., Fowler, P., Schlicht, H. J., Vitiello, A., Chesnut, R. C., Fiaccadori, F., Ferrari, C. Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein Journal of Virology  1993 67:2376-2380  PMID:7680391  PMCID:PMC240403
  • Missale, G., Redeker, A., Person, J., Fowler, P., Guilhot, S., Schlicht, H. J., Ferrari, C., Chisari, F. V. HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis Journal of Experimental Medicine  1993 177:751-762  DOI:10.1084/jem.177.3.751  PMID:7679709
  • Guilhot, S., Fowler, P., Portillo, G., Margolskee, R. F., Ferrari, C., Bertoletti, A., Chisari, F. V. Hepatitis B virus (HBV)-specific cytotoxic T-cell response in humans: production of target cells by stable expression of HBV-encoded proteins in immortalized human B-cell lines Journal of Virology  1992 66:2670-2678  PMID:1313893  PMCID:PMC241021
  • Penna, A., Fowler, P., Bertoletti, A., Guilhot, S., Moss, B., Margolskee, R. F., Cavalli, A., Valli, A., Fiaccadori, F., Chisari, F. V., Ferrari, C. Hepatitis B virus (HBV)-specific cytotoxic T-cell (CTL) response in humans: characterization of HLA class II-restricted CTLs that recognize endogenously synthesized HBV envelope antigens Journal of Virology  1992 66:1193-1198  PMID:1731098  PMCID:PMC240825
  • Penna, A., Bertoletti, A., Cavalli, A., Valli, A., Missale, G., Pilli, M., Marchelli, S., Giuberti, T., Fowler, P., Chisari, F. V., Fiaccadori, F., Ferrari, C. Fine specificity of the human T cell response to hepatitis B virus core antigen Archives of Virology  1992 23-28  PMID:1280506
  • Penna, A., Chisari, F. V., Bertoletti, A., Missale, G., Fowler, P., Giuberti, T., Fiaccadori, F., Ferrari, C. Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen Journal of Experimental Medicine  1991 174:1565-1570  DOI:10.1084/jem.174.6.1565  PMID:1720813
  • Bertoletti, A., Ferrari, C., Fiaccadori, F., Penna, A., Margolskee, R., Schlicht, H. J., Fowler, P., Guilhot, S., Chisari, F. V. HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen Proceedings of the National Academy of Sciences of the United States of America  1991 88:10445-10449  DOI:10.1073/pnas.88.23.10445  PMID:1660137
  • Ferrari, C., Bertoletti, A., Penna, A., Cavalli, A., Valli, A., Missale, G., Pilli, M., Fowler, P., Giuberti, T., Chisari, F. V., Fiaccadori, F. Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen Journal of Clinical Investigation  1991 88:214-222  DOI:10.1172/jci115280  PMID:1711541