recent publications

• academic article

  • Bergum, P. W., Cruikshank, A., Maki, S. L., Kelly, C. R., Ruf, W., Vlasuk, G. P. Role of zymogen and activated factor x as scaffolds for the inhibition of the blood coagulation factor viia-tissue factor complex by recombinant nematode anticoagulant protein c2 Journal of Biological Chemistry  2001 276:10063-10071  DOI:10.1074/jbc.M009116200  PMID:11139576
  • Donate, F., Kelly, C. R., Ruf, W., Edgington, T. S. Dimerization of tissue factor supports solution-phase autoactivation of factor vii without influencing proteolytic activation of factor x Biochemistry  2000 39:11467-11476  DOI:10.1021/bi000986p  PMID:10985793
  • Kelly, C. R., Dickinson, C. D., Ruf, W. Ca2+ binding to the first epidermal growth factor module of coagulation factor viia is important for cofactor interaction and proteolytic function Journal of Biological Chemistry  1997 272:17467-17472  DOI:10.1074/jbc.272.28.17467  PMID:9211891
  • Dickinson, C. D., Kelly, C. R., Ruf, W. Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor viia Proceedings of the National Academy of Sciences of the United States of America  1996 93:14379-14384  DOI:10.1073/pnas.93.25.14379  PMID:8962059
  • Kelly, C. R., Schullek, J. R., Ruf, W., Edgington, T. S. Tissue factor residue asp(44) regulates catalytic function of the bound proteinase factor vlla Biochemical Journal  1996 315:145-151  PMID:8670099  PMCID:PMC1217163
  • Ruf, W., Kelly, C. R., Schullek, J. R., Martin, D. M. A., Polikarpov, I., Boys, C. W. G., Tuddenham, E. G. D., Edgington, T. S. Energetic contributions and topographical organization of ligand-binding residues of tissue factor Biochemistry  1995 34:6310-6315  DOI:10.1021/bi00019a008  PMID:7756258