recent publications

• academic article

  • Roberts, V. A., Pique, M. E., Hsu, S., Li, S., Slupphaug, G., Rambo, R. P., Jamison, J. W., Liu, T., Lee, J. H., Tainer, J. A., Ten Eyck, L. F., Woods, V. L. Combining h/d exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase Nucleic Acids Research  2012 40:6070-6081  DOI:10.1093/nar/gks291  PMID:22492624  PMCID:PMC3401472
  • Trinh, M. H., Odorico, M., Pique, M. E., Teulon, J. M., Roberts, V. A., Ten Eyck, L. F., Getzoff, E. D., Parot, P., Chen, S. W. W., Pellequer, J. L. Computational reconstruction of multidomain proteins using atomic force microscopy data Structure  2012 20:113-120  DOI:10.1016/j.str.2011.10.023  PMID:22244760  PMCID:PMC3264848
  • Fan, L., Fuss, J. O., Cheng, Q. J., Arvai, A. S., Hammel, M., Roberts, V. A., Cooper, P. K., Tainer, J. A. Xpd helicase structures and activities: Insights into the cancer and aging phenotypes from xpd mutations Cell  2008 133:789-800  DOI:10.1016/j.cell.2008.04.030  PMID:18510924  PMCID:PMC3055247
  • Brudler, R., Hitomi, K., Daiyasu, H., Toh, H., Kucho, K., Ishiura, M., Kanehisa, M., Roberts, V. A., Todo, T., Tainer, J. A., Getzoff, E. D. Identification of a new cryptochrome class: Structure, function, and evolution Molecular Cell  2003 11:59-67  DOI:10.1016/s1097-2765(03)00008-x  PMID:12535521
  • Castagnetto, J. M., Hennessy, S. W., Roberts, V. A., Getzoff, E. D., Tainer, J. A., Pique, M. E. MDB: The metalloprotein database and browser at The Scripps Research Institute Nucleic Acids Research  2002 30:379-382  DOI:10.1093/nar/30.1.379  PMID:11752342
  • Pellequer, J. L., Chen, S. W. W., Feeney, A. J., Zhao, B., Kao, H. I., Karu, A. E., Li, K., Li, Q. X., Roberts, V. A. Architecture of antibody binding sites for polynuclear aromatic hydrocarbons ACS Symposium Series  2001 778:398-416  DOI:10.1021/bk-2001-0778.ch024
  • Thayer, M. M., Olender, E. H., Arvai, A. S., Koike, C. K., Canestrelli, I. L., Stewart, J. D., Benkovic, S. J., Getzoff, E. D., Roberts, V. A. Structural basis for amide hydrolysis catalyzed by the 43C9 antibody Journal of Molecular Biology  1999 291:329-345  DOI:10.1006/jmbi.1999.2960  PMID:10438624
  • Pellequer, J. L., Chen, S. W. W., Roberts, V. A., Tainer, J. A., Getzoff, E. D. Unraveling the effect of changes in conformation and compactness at the antibody V(L)-V(H) interface upon antigen binding Journal of Molecular Recognition  1999 12:267-275  DOI:10.1002/(sici)1099-1352(199907/08)12:4<267::aid-jmr465>3.0.co;2-9  PMID:10440998
  • Jung, Y. S., Roberts, V. A., Stout, C. D., Burgess, B. K. Complex formation between azotobacter vinelandii ferredoxin i and its physiological electron donor nadph-ferredoxin reductase Journal of Biological Chemistry  1999 274:2978-2987  DOI:10.1074/jbc.274.5.2978  PMID:9915836
  • Roberts, V. A., Nachman, R. J., Coast, G. M., Hariharan, M., Chung, J. S., Holman, G. M., Williams, H., Tainer, J. A. Consensus chemistry and beta-turn conformation of the active core of the insect kinin neuropeptide family Chemistry & Biology  1997 4:105-117  DOI:10.1016/s1074-5521(97)90254-4  PMID:9190285
  • Crowder, M. W., Stewart, J. D., Roberts, V. A., Bender, C. J., Tevelrakh, E., Peisach, J., Getzoff, E. D., Gaffney, B. J., Benkovic, S. J. Spectroscopic studies on the designed metal-binding sites of the 43c9 single-chain antibody Journal of the American Chemical Society  1995 117:5627-5634  DOI:10.1021/ja00126a003
  • Roberts, V. A., Getzoff, E. D. Metalloantibody design FASEB Journal  1995 9:94-100  PMID:7821766
  • Friedman, A. R., Roberts, V. A., Tainer, J. A. Predicting molecular-interactions and inducible complementarity - fragment docking of fab-peptide complexes Proteins-Structure Function and Genetics  1994 20:15-24  DOI:10.1002/prot.340200104  PMID:7529922
  • Stewart, J. D., Roberts, V. A., Thomas, N. R., Getzoff, E. D., Benkovic, S. J. Site-directed mutagenesis of a catalytic antibody - an arginine and a histidine residue play key roles Biochemistry  1994 33:1994-2003  DOI:10.1021/bi00174a004  PMID:8117656
  • Roberts, V. A., Stewart, J., Benkovic, S. J., Getzoff, E. D. Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization Journal of Molecular Biology  1994 235:1098-1116  DOI:10.1006/jmbi.1994.1060  PMID:8289310
  • Stewart, J. D., Roberts, V. A., Crowder, M. W., Getzoff, E. D., Benkovic, S. J. Creation of a novel biosensor for zinc(II) Journal of the American Chemical Society  1994 116:415-416  DOI:10.1021/ja00080a065
  • Tainer, J. A., Roberts, V. A., Getzoff, E. D. Protein metal-binding sites Current Opinion in Biotechnology  1992 3:378-387  DOI:10.1016/0958-1669(92)90166-G  PMID:1368439
  • Tainer, J. A., Roberts, V. A., Getzoff, E. D. Metal-binding sites in proteins Current Opinion in Biotechnology  1991 2:582-591  DOI:10.1016/0958-1669(91)90084-i  PMID:1367679
  • Roberts, V. A., Freeman, H. C., Olson, A. J., Tainer, J. A., Getzoff, E. D. Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c Journal of Biological Chemistry  1991 266:13431-13441  PMID:1649191
  • Nachman, R. J., Roberts, V. A., Dyson, H. J., Holman, G. M., Tainer, J. A. Active conformation of an insect neuropeptide family Proceedings of the National Academy of Sciences of the United States of America  1991 88:4518-4522  DOI:10.1073/pnas.88.10.4518  PMID:2034692
  • Tainer, J. A., Deal, C. D., Geysen, H. M., Roberts, V. A., Getzoff, E. D. Defining antibody-antigen recognition: towards engineered antibodies and epitopes International Reviews of Immunology  1991 7:165-188  PMID:1721650
  • Roberts, V. A., Fisher, C. L., Redford, S. M., McRee, D. E., Parge, H. E., Getzoff, E. D., Tainer, J. A. Mechanism and atomic structure of superoxide dismutase Free Radical Research Communications  1991 12-3:269-278  DOI:10.3109/10715769109145795  PMID:1649094
  • Fisher, C. L., Hallewell, R. A., Roberts, V. A., Tainer, J. A., Getzoff, E. D. Probing the structural basis for enzyme-substrate recognition in Cu, Zn superoxide dismutase Free Radical Research Communications  1991 12-3:287-296  DOI:10.3109/10715769109145797  PMID:1649096
  • Roberts, V. A., Iverson, B. L., Iverson, S. A., Benkovic, S. J., Lerner, R. A., Getzoff, E. D., Tainer, J. A. Antibody remodeling - a general-solution to the design of a metal-coordination site in an antibody-binding pocket Proceedings of the National Academy of Sciences of the United States of America  1990 87:6654-6658  DOI:10.1073/pnas.87.17.6654  PMID:2395868
  • Iverson, B. L., Iverson, S. A., Roberts, V. A., Getzoff, E. D., Tainer, J. A., Benkovic, S. J., Lerner, R. A. Metalloantibodies Science  1990 249:659-662  DOI:10.1126/science.2116666  PMID:2116666
  • Chien, N. C., Roberts, V. A., Giusti, A. M., Scharff, M. D., Getzoff, E. D. Significant structural and functional change of an antigen-binding site by a distant amino-acid substitution - proposal of a structural mechanism Proceedings of the National Academy of Sciences of the United States of America  1989 86:5532-5536  DOI:10.1073/pnas.86.14.5532  PMID:2748602
  • Behar, S. M., Chien, N. C., Corbet, S., Diamond, B., Getzoff, E. D., Lustgarten, D., Roberts, V. A., Scharff, M. D., Shin, S. U. Impact of somatic mutation on the S107(T15) heavy-chain V region of antibodies reactive with self and nonself Cold Spring Harbor Symposia on Quantitative Biology  1989 54:921-931  PMID:2518013
  • Tainer, J. A., Hallewell, R. A., Roberts, V. A., Parge, H. E., Getzoff, E. D. Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase Basic Life Sciences  1988 49:635-640  DOI:10.1007/978-1-4684-5568-7_100  PMID:3250519