recent publications
-
academic article
- Roberts, V. A., Pique, M. E., Hsu, S., Li, S., Slupphaug, G., Rambo, R. P., Jamison, J. W., Liu, T., Lee, J. H., Tainer, J. A., Ten Eyck, L. F., Woods, V. L. Combining h/d exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase Nucleic Acids Research 2012 40:6070-6081 DOI:10.1093/nar/gks291 PMID:22492624 PMCID:PMC3401472
- Trinh, M. H., Odorico, M., Pique, M. E., Teulon, J. M., Roberts, V. A., Ten Eyck, L. F., Getzoff, E. D., Parot, P., Chen, S. W. W., Pellequer, J. L. Computational reconstruction of multidomain proteins using atomic force microscopy data Structure 2012 20:113-120 DOI:10.1016/j.str.2011.10.023 PMID:22244760 PMCID:PMC3264848
- Fan, L., Fuss, J. O., Cheng, Q. J., Arvai, A. S., Hammel, M., Roberts, V. A., Cooper, P. K., Tainer, J. A. Xpd helicase structures and activities: Insights into the cancer and aging phenotypes from xpd mutations Cell 2008 133:789-800 DOI:10.1016/j.cell.2008.04.030 PMID:18510924 PMCID:PMC3055247
- Brudler, R., Hitomi, K., Daiyasu, H., Toh, H., Kucho, K., Ishiura, M., Kanehisa, M., Roberts, V. A., Todo, T., Tainer, J. A., Getzoff, E. D. Identification of a new cryptochrome class: Structure, function, and evolution Molecular Cell 2003 11:59-67 DOI:10.1016/s1097-2765(03)00008-x PMID:12535521
- Castagnetto, J. M., Hennessy, S. W., Roberts, V. A., Getzoff, E. D., Tainer, J. A., Pique, M. E. MDB: The metalloprotein database and browser at The Scripps Research Institute Nucleic Acids Research 2002 30:379-382 DOI:10.1093/nar/30.1.379 PMID:11752342
- Pellequer, J. L., Chen, S. W. W., Feeney, A. J., Zhao, B., Kao, H. I., Karu, A. E., Li, K., Li, Q. X., Roberts, V. A. Architecture of antibody binding sites for polynuclear aromatic hydrocarbons ACS Symposium Series 2001 778:398-416 DOI:10.1021/bk-2001-0778.ch024
- Thayer, M. M., Olender, E. H., Arvai, A. S., Koike, C. K., Canestrelli, I. L., Stewart, J. D., Benkovic, S. J., Getzoff, E. D., Roberts, V. A. Structural basis for amide hydrolysis catalyzed by the 43C9 antibody Journal of Molecular Biology 1999 291:329-345 DOI:10.1006/jmbi.1999.2960 PMID:10438624
- Pellequer, J. L., Chen, S. W. W., Roberts, V. A., Tainer, J. A., Getzoff, E. D. Unraveling the effect of changes in conformation and compactness at the antibody V(L)-V(H) interface upon antigen binding Journal of Molecular Recognition 1999 12:267-275 DOI:10.1002/(sici)1099-1352(199907/08)12:4<267::aid-jmr465>3.0.co;2-9 PMID:10440998
- Jung, Y. S., Roberts, V. A., Stout, C. D., Burgess, B. K. Complex formation between azotobacter vinelandii ferredoxin i and its physiological electron donor nadph-ferredoxin reductase Journal of Biological Chemistry 1999 274:2978-2987 DOI:10.1074/jbc.274.5.2978 PMID:9915836
- Roberts, V. A., Nachman, R. J., Coast, G. M., Hariharan, M., Chung, J. S., Holman, G. M., Williams, H., Tainer, J. A. Consensus chemistry and beta-turn conformation of the active core of the insect kinin neuropeptide family Chemistry & Biology 1997 4:105-117 DOI:10.1016/s1074-5521(97)90254-4 PMID:9190285
- Crowder, M. W., Stewart, J. D., Roberts, V. A., Bender, C. J., Tevelrakh, E., Peisach, J., Getzoff, E. D., Gaffney, B. J., Benkovic, S. J. Spectroscopic studies on the designed metal-binding sites of the 43c9 single-chain antibody Journal of the American Chemical Society 1995 117:5627-5634 DOI:10.1021/ja00126a003
- Roberts, V. A., Getzoff, E. D. Metalloantibody design FASEB Journal 1995 9:94-100 PMID:7821766
- Friedman, A. R., Roberts, V. A., Tainer, J. A. Predicting molecular-interactions and inducible complementarity - fragment docking of fab-peptide complexes Proteins-Structure Function and Genetics 1994 20:15-24 DOI:10.1002/prot.340200104 PMID:7529922
- Stewart, J. D., Roberts, V. A., Thomas, N. R., Getzoff, E. D., Benkovic, S. J. Site-directed mutagenesis of a catalytic antibody - an arginine and a histidine residue play key roles Biochemistry 1994 33:1994-2003 DOI:10.1021/bi00174a004 PMID:8117656
- Roberts, V. A., Stewart, J., Benkovic, S. J., Getzoff, E. D. Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization Journal of Molecular Biology 1994 235:1098-1116 DOI:10.1006/jmbi.1994.1060 PMID:8289310
- Stewart, J. D., Roberts, V. A., Crowder, M. W., Getzoff, E. D., Benkovic, S. J. Creation of a novel biosensor for zinc(II) Journal of the American Chemical Society 1994 116:415-416 DOI:10.1021/ja00080a065
- Tainer, J. A., Roberts, V. A., Getzoff, E. D. Protein metal-binding sites Current Opinion in Biotechnology 1992 3:378-387 DOI:10.1016/0958-1669(92)90166-G PMID:1368439
- Tainer, J. A., Roberts, V. A., Getzoff, E. D. Metal-binding sites in proteins Current Opinion in Biotechnology 1991 2:582-591 DOI:10.1016/0958-1669(91)90084-i PMID:1367679
- Roberts, V. A., Freeman, H. C., Olson, A. J., Tainer, J. A., Getzoff, E. D. Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c Journal of Biological Chemistry 1991 266:13431-13441 PMID:1649191
- Nachman, R. J., Roberts, V. A., Dyson, H. J., Holman, G. M., Tainer, J. A. Active conformation of an insect neuropeptide family Proceedings of the National Academy of Sciences of the United States of America 1991 88:4518-4522 DOI:10.1073/pnas.88.10.4518 PMID:2034692
- Tainer, J. A., Deal, C. D., Geysen, H. M., Roberts, V. A., Getzoff, E. D. Defining antibody-antigen recognition: towards engineered antibodies and epitopes International Reviews of Immunology 1991 7:165-188 PMID:1721650
- Roberts, V. A., Fisher, C. L., Redford, S. M., McRee, D. E., Parge, H. E., Getzoff, E. D., Tainer, J. A. Mechanism and atomic structure of superoxide dismutase Free Radical Research Communications 1991 12-3:269-278 DOI:10.3109/10715769109145795 PMID:1649094
- Fisher, C. L., Hallewell, R. A., Roberts, V. A., Tainer, J. A., Getzoff, E. D. Probing the structural basis for enzyme-substrate recognition in Cu, Zn superoxide dismutase Free Radical Research Communications 1991 12-3:287-296 DOI:10.3109/10715769109145797 PMID:1649096
- Roberts, V. A., Iverson, B. L., Iverson, S. A., Benkovic, S. J., Lerner, R. A., Getzoff, E. D., Tainer, J. A. Antibody remodeling - a general-solution to the design of a metal-coordination site in an antibody-binding pocket Proceedings of the National Academy of Sciences of the United States of America 1990 87:6654-6658 DOI:10.1073/pnas.87.17.6654 PMID:2395868
- Iverson, B. L., Iverson, S. A., Roberts, V. A., Getzoff, E. D., Tainer, J. A., Benkovic, S. J., Lerner, R. A. Metalloantibodies Science 1990 249:659-662 DOI:10.1126/science.2116666 PMID:2116666
- Chien, N. C., Roberts, V. A., Giusti, A. M., Scharff, M. D., Getzoff, E. D. Significant structural and functional change of an antigen-binding site by a distant amino-acid substitution - proposal of a structural mechanism Proceedings of the National Academy of Sciences of the United States of America 1989 86:5532-5536 DOI:10.1073/pnas.86.14.5532 PMID:2748602
- Behar, S. M., Chien, N. C., Corbet, S., Diamond, B., Getzoff, E. D., Lustgarten, D., Roberts, V. A., Scharff, M. D., Shin, S. U. Impact of somatic mutation on the S107(T15) heavy-chain V region of antibodies reactive with self and nonself Cold Spring Harbor Symposia on Quantitative Biology 1989 54:921-931 PMID:2518013
- Tainer, J. A., Hallewell, R. A., Roberts, V. A., Parge, H. E., Getzoff, E. D. Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase Basic Life Sciences 1988 49:635-640 DOI:10.1007/978-1-4684-5568-7_100 PMID:3250519