recent publications

• academic article

  • Chung, C. C., Ohwaki, K., Schneeweis, J. E., Stec, E., Varnerin, J. P., Goudreau, P. N., Chang, A., Cassaday, J., Yang, L. H., Yamakawa, T., Kornienko, O., Hodder, P., et al. A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme a production Assay and Drug Development Technologies  2008 6:361-374  DOI:10.1089/adt.2007.105  PMID:18452391
  • Strowski, M. Z., Cashen, D. E., Birzin, E. T., Yang, L. H., Singh, V., Jacks, T. M., Nowak, K. W., Rohrer, S. P., Patchett, A. A., Smith, R. G., Schaeffer, J. M. Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist Endocrinology  2006 147:4664-4673  DOI:10.1210/en.2006-0274  PMID:16857751
  • Palyha, O. C., Feighner, S. D., Tan, C. P., McKee, K. K., Hreniuk, D. L., Gao, Y. D., Schleim, K. D., Yang, L. H., Morriello, G. J., Nargund, R., Patchett, A. A., Howard, A. D., et al. Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans Molecular Endocrinology  2000 14:160-169  DOI:10.1210/me.14.1.160  PMID:10628755
  • Yang, L. H., Morriello, G., Leung, K., Jacks, T., Cheng, K., Schleim, K. D., Smith, R., Patchett, A. A. Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues Bioorganic & Medicinal Chemistry Letters  1999 9:1761-1766  DOI:10.1016/S0960-894X(99)00286-3  PMID:10406638
  • Smith, R. G., Palyha, O. C., Feighner, S. D., Tan, C. P., McKee, K. K., Hreniuk, D. L., Yang, L. H., Morriello, G., Nargund, R., Patchett, A. A., Howard, A. D. Growth hormone releasing substances: types and their receptors Hormone Research  1999 51:1-8  DOI:10.1159/000044375  PMID:10592437
  • Yang, L. H., Berk, S. C., Rohrer, S. P., Mosley, R. T., Guo, L. Q., Underwood, D. J., Arison, B. H., Birzin, E. T., Hayes, E. C., Mitra, S. W., Parmar, R. M., Cheng, K., et al. Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2 Proceedings of the National Academy of Sciences of the United States of America  1998 95:10836-10841  DOI:10.1073/pnas.95.18.10836  PMID:9724791  PMCID:PMC27982
  • Yang, L. H., Morriello, G., Patchett, A. A., Leung, K., Jacks, T., Cheng, K., Schleim, K. D., Feeney, W., Chan, W. W. S., Chiu, S. H. L., Smith, R. G. 1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue Journal of Medicinal Chemistry  1998 41:2439-2441  DOI:10.1021/jm9800191  PMID:9651148
  • Yang, L. H., Morriello, G., Pan, Y. P., Nargund, R. P., Barakat, K., Prendergast, K., Cheng, K., Chan, W. W. S., Smith, R. G., Patchett, A. A. Tripeptide growth hormone secretagogues Bioorganic & Medicinal Chemistry Letters  1998 8:759-764  DOI:10.1016/s0960-894x(98)00103-6  PMID:9871537
  • Yang, L. H., Morriello, G., Prendergast, K., Cheng, K., Jacks, T., Chan, W. W. S., Schleim, K. D., Smith, R. G., Patchett, A. A. Potent 3-spiropiperidine growth hormone secretagogues Bioorganic & Medicinal Chemistry Letters  1998 8:107-112  DOI:10.1016/s0960-894x(97)10199-8  PMID:9925440
  • Rohrer, S. P., Birzin, E. T., Mosley, R. T., Berk, S. C., Hutchins, S. M., Shen, D. M., Xiong, Y. S., Hayes, E. C., Parmar, R. M., Foor, F., Mitra, S. W., Degrado, S. J., et al. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry Science  1998 282:737-740  DOI:10.1126/science.282.5389.737  PMID:9784130