recent publications

• academic article

  • Liu, T., Ma, M., Ge, H. M., Yang, C., Cleveland, J., Shen, B. Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin Bioorganic & Medicinal Chemistry Letters  2015  DOI:10.1016/j.bmcl.2015.05.078  PMID:26071634  PMCID:PMC4607584
  • Yin, X., Cheng, H., Lin, Y., Wineinger, N. E., Zhou, F., Sheng, Y., Yang, C., Li, P., Li, F., Shen, C., Yang, S., Schork, N. J., et al. A weighted polygenic risk score using 14 known susceptibility variants to estimate risk and age onset of psoriasis in han chinese PLoS One  2015 10:e0125369  DOI:10.1371/journal.pone.0125369  PMID:25933357  PMCID:PMC4416725
  • Seo, J. W., Ma, M., Kwong, T., Ju, J., Lim, S. K., Jiang, H., Lohman, J. R., Yang, C., Cleveland, J., Zazopoulos, E., Farnet, C. M., Shen, B. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues Biochemistry  2014 53:7854-7865  DOI:10.1021/bi501396v  PMID:25405956  PMCID:PMC4270375
  • Wang, H., Yang, C., Doherty, J. R., Roush, W. R., Cleveland, J. L., Bannister, T. D. Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors Journal of Medicinal Chemistry  2014 57:7317-7324  DOI:10.1021/jm500640x  PMID:25068893  PMCID:PMC4161152
  • Lu, Y., Wu, Y., Feng, X., Shen, R., Wang, J. H., Fallahi, M., Li, W., Yang, C., Hankey, W., Zhao, W., Ganju, R. K., Li, M. O., et al. CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis Journal of Clinical Investigation  2014 124:1672-1684  DOI:10.1172/jci63139  PMID:24614102  PMCID:PMC3973114
  • Doherty, J. R., Yang, C., Scott, K. E. N., Cameron, M. D., Fallahi, M., Li, W., Hall, M. A., Amelio, A. L., Mishra, J. K., Li, F., Tortosa, M., Genau, H. M., et al. Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis Cancer Research  2014 74:908-920  DOI:10.1158/0008-5472.can-13-2034  PMID:24285728  PMCID:PMC3946415
  • Jeso, V., Yang, C., Cameron, M. D., Cleveland, J. L., Micalizio, G. C. Synthesis and SAR of lehualide B: A marine-derived natural product with potent anti-multiple myeloma activity ACS Chemical Biology  2013 8:1241-1252  DOI:10.1021/cb300582s  PMID:23547759  PMCID:PMC3758376
  • Low, L. Y., Yang, C., Perego, M., Osterman, A., Liddington, R. Role of net charge on catalytic domain and influence of cell wall binding domain on bactericidal activity, specificity, and host range of phage lysins Journal of Biological Chemistry  2011 286:34391-34403  DOI:10.1074/jbc.M111.244160  PMID:21816821  PMCID:PMC3190764
  • Huang, H. N., Jeon, M. S., Liao, L. J., Yang, C., Elly, C., Yates, J. R., Liu, Y. C. K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling Immunity  2010 33:60-70  DOI:10.1016/j.immuni.2010.07.002  PMID:20637659  PMCID:PMC2927827
  • Nilsson, L. M., Keller, U. B., Yang, C., Nilsson, J. A., Cleveland, J. L., Roussel, M. F. Ink4c is dispensable for tumor suppression in myc-induced b-cell lymphomagenesis Oncogene  2007 26:2833-2839  DOI:10.1038/sj.onc.1210104  PMID:17099725
  • Yang, C., Penczek, P. A., Leith, A., Asturias, F. J., Ng, E. G., Glaeser, R. M., Frank, J. The parallelization of SPIDER on distributed-memory computers using MPI Journal of Structural Biology  2007 157:240-249  DOI:10.1016/j.jsb.2006.05.011  PMID:16859923
  • Venuprasad, K., Elly, C., Gao, M., Salek-Ardakani, S., Harada, Y., Luo, J. L., Yang, C., Croft, M., Inoue, K., Karin, M., Liu, Y. C. Convergence of itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation Journal of Clinical Investigation  2006 116:1117-1126  DOI:10.1172/jci26858  PMID:16557301  PMCID:PMC1409741
  • Low, L. Y., Yang, C., Perego, M., Osterman, A., Liddington, R. C. Structure and lytic activity of a bacillus anthracis prophage endolysin Journal of Biological Chemistry  2005 280:35433-35439  DOI:10.1074/jbc.M502723200  PMID:16103125
  • Wester, M. R., Yano, J. K., Schoch, G. A., Yang, C., Griffin, K. J., Stout, C. D., Johnson, E. F. The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution Journal of Biological Chemistry  2004 279:35630-35637  DOI:10.1074/jbc.M405427200  PMID:15181000