recent publications

• academic article

  • Hackwon, D., Kim, S. J., Lee, C. W., Kim, H. W., Park, H. H., Kim, H. M., Park, H., Park, H., Lee, J. H. Crystal structure of UbiX, an aromatic acid decarboxylase from the psychrophilic bacterium Colwellia psychrerythraea that undergoes FMN-induced conformational changes Scientific Reports  2015 5:8196  DOI:10.1038/srep08196  PMID:25645665  PMCID:PMC4316190
  • Herr, D. R., Lee, C. W., Wang, W., Ware, A., Rivera, R., Chun, J. Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development Journal of Biological Chemistry  2013 288:29882-29889  DOI:10.1074/jbc.M113.510099  PMID:24003216  PMCID:PMC3795286
  • Ward, A. B., Szewczyk, P., Grimard, V., Lee, C. W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D. J., Falson, P. G., et al. Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain Proceedings of the National Academy of Sciences of the United States of America  2013 110:13386-13391  DOI:10.1073/pnas.1309275110  PMID:23901103  PMCID:PMC3746859
  • Herr, K. J., Herr, D. R., Lee, C. W., Noguchi, K., Chun, J. Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA1) signaling Proceedings of the National Academy of Sciences of the United States of America  2011 108:15444-15449  DOI:10.1073/pnas.1106129108  PMID:21878565  PMCID:PMC3174597
  • Choi, J. W., Gardell, S. E., Herr, D. R., Rivera, R., Lee, C. W., Noguchi, K., Teo, S. T., Yung, Y. C., Lu, M., Kennedy, G., Chun, J. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation Proceedings of the National Academy of Sciences of the United States of America  2011 108:751-756  DOI:10.1073/pnas.1014154108  PMID:21177428  PMCID:PMC3021041
  • Lee, C. W., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of creb binding protein Biochemistry  2010 49:9964-9971  DOI:10.1021/bi1012996  PMID:20961098  PMCID:PMC2982890
  • Lee, C. W., Ferreon, J. C., Ferreon, A. C. M., Arai, M., Wright, P. E. Graded enhancement of p53 binding to creb-binding protein (cbp) by multisite phosphorylation Proceedings of the National Academy of Sciences of the United States of America  2010 107:19290-19295  DOI:10.1073/pnas.1013078107  PMID:20962272  PMCID:PMC2984141
  • Lee, C. W., Choi, J. W., Chun, J. Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis Archives of Pharmacal Research  2010 33:1567-1574  DOI:10.1007/s12272-010-1008-5  PMID:21052934
  • Choi, J. W., Herr, D. R., Noguchi, K., Yung, Y. C., Lee, C. W., Mutoh, T., Lin, M. E., Teo, S. T., Park, K. E., Mosley, A. N., Chun, J. LPA receptors: subtypes and biological actions Annual Review of Pharmacology and Toxicology  2010 50:157-186  DOI:10.1146/annurev.pharmtox.010909.105753  PMID:20055701
  • Ferreon, J. C., Lee, C. W., Arai, M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Cooperative regulation of p53 by modulation of ternary complex formation with cbp/p300 and hdm2 Proceedings of the National Academy of Sciences of the United States of America  2009 106:6591-6596  DOI:10.1073/pnas.0811023106  PMID:19357310  PMCID:PMC2672497
  • Lee, C. W., Arai, M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Mapping the interactions of the p53 transactivation domain with the kix domain of cbp Biochemistry  2009 48:2115-2124  DOI:10.1021/bi802055v  PMID:19220000  PMCID:PMC2765525
  • Choi, J. W., Lee, C. W., Chun, J. Biological roles of lysophospholipid receptors revealed by genetic null mice: An update Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids  2008 1781:531-539  DOI:10.1016/j.bbalip.2008.03.004  PMID:18407842  PMCID:PMC2657083
  • Lee, C. W., Kim, N. H., Choi, H. K., Sun, Y., Nam, J. S., Rhee, H. J., Chun, J., Huh, S. O. Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated by mitogen- and stress-activated protein kinase-1 Journal of Cellular Biochemistry  2008 104:785-794  DOI:10.1002/jcb.21663  PMID:18172855
  • Lee, C. W., Rivera, R., Dubin, A. E., Chun, J. LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation Journal of Biological Chemistry  2007 282:4310-4317  DOI:10.1074/jbc.M610826200  PMID:17166850
  • Lee, C. W., Rivera, R., Gardell, S., Dubin, A. E., Chun, J. GPR92 as a new G12/13 and Gq-coupled lysophosphatidic acid receptor that increases cAMP: LPA5 Journal of Biological Chemistry  2006 281:23589-23597  DOI:10.1074/jbc.M603670200  PMID:16774927
  • Lee, C. W., Martinek, V., Usas, A., Musgrave, D., Pickvance, E. A., Robbins, P., Moreland, M. S., Fu, F. H., Huard, J. Muscle-based gene therapy and tissue engineering for treatment of growth plate injuries Journal of Pediatric Orthopaedics  2002 22:565-572  DOI:10.1097/01.bpo.0000026337.10173.bd  PMID:12198455