recent publications

• academic article

  • Otomo, T., Tomchick, D. R., Otomo, C., Machius, M., Rosen, M. K. Crystal structure of the Formin mDia1 in autoinhibited conformation PLoS One  2010 5:e12896  DOI:10.1371/journal.pone.0012896  PMID:20927343  PMCID:PMC2948019
  • Kreishman-Deitrick, M., Goley, E. D., Burdine, L., Denison, C., Egile, C., Li, R., Murali, N., Kodadek, T. J., Welch, M. D., Rosen, M. K. Nmr analyses of the activation of the arp2/3 complex by neuronal wiskott-aldrich syndrome protein Biochemistry  2005 44:15247-15256  DOI:10.1021/bi051065n  PMID:16285728
  • Shemesh, T., Otomo, T., Rosen, M. K., Bershadsky, A. D., Kozlov, M. M. A novel mechanism of actin filament processive capping by formin: Solution of the rotation paradox Journal of Cell Biology  2005 170:889-893  DOI:10.1083/jcb.200504156  PMID:16157699  PMCID:PMC2171452
  • Otomo, T., Otomo, C., Tomchick, D. R., Machius, M., Rosen, M. K. Structural basis of Rho GTPase-mediated activation of the formin rndia1 Molecular Cell  2005 18:273-281  DOI:10.1016/j.molcel.2005.04.002  PMID:15866170
  • Otomo, T., Tomchick, D. R., Otomo, C., Panchal, S. C., Machius, M., Rosen, M. K. Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain Nature  2005 433:488-494  DOI:10.1038/nature03251  PMID:15635372
  • Seth, A., Otomo, T., Yin, H. L., Rosen, M. K. Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling Biochemistry  2003 42:3997-4008  DOI:10.1021/bi026881z  PMID:12680752