recent publications

• academic article

  • Li, X. H., Song, X. Y., Kamenecka, T. M., Cameron, M. D. Discovery of a highly selective CYP3A4 inhibitor suitable for reaction phenotyping studies and differentiation of CYP3A4 and CYP3A5 Drug Metabolism and Disposition  2012 40:1803-1809  DOI:10.1124/dmd.112.046144  PMID:22696420  PMCID:PMC3422543
  • Arnold, C. N., Pirie, E., Dosenovic, P., McInerney, G. M., Xia, Y., Wang, N., Li, X. H., Siggs, O. M., Hedestam, G. B. K., Beutler, B. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity Proceedings of the National Academy of Sciences of the United States of America  2012 109:12286-12293  DOI:10.1073/pnas.1209134109  PMID:22761313  PMCID:PMC3411946
  • Brandl, K., Tomisato, W., Li, X. H., Neppl, C., Pirie, E., Falk, W., Xia, Y., Moresco, E. M. Y., Baccala, R., Theofilopoulos, A. N., Schnabl, B., Beutler, B. Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice Proceedings of the National Academy of Sciences of the United States of America  2012 109:12650-12655  DOI:10.1073/pnas.1210366109  PMID:22802641  PMCID:PMC3412000
  • Siggs, O. M., Xiao, N. M., Wang, Y., Shi, H. X., Tomisato, W., Li, X. H., Xia, Y., Beutler, B. IRhom2 is required for the secretion of mouse TNFα Blood  2012 119:5769-5771  DOI:10.1182/blood-2012-03-417949  PMID:22550345  PMCID:PMC3382936
  • Li, X. H., Cameron, M. D. Potential role of a quetiapine metabolite in quetiapine-induced neutropenia and agranulocytosis Chemical Research in Toxicology  2012 25:1004-1011  DOI:10.1021/tx2005635  PMID:22506851
  • Song, X. Y., Li, X. H., Ruiz, C. H., Yin, Y., Feng, Y., Kamenecka, T. M., Cameron, M. D. Imidazopyridines as selective CYP3A4 inhibitors Bioorganic & Medicinal Chemistry Letters  2012 22:1611-1614  DOI:10.1016/j.bmcl.2011.12.125  PMID:22264486  PMCID:PMC4481867
  • Siggs, O. M., Li, X. H., Xia, Y., Beutler, B. ZBTB1 is a determinant of lymphoid development Journal of Experimental Medicine  2012 209:19-27  DOI:10.1084/jem.20112084  PMID:22201126  PMCID:PMC3260866
  • Krebs, P., Fan, W. W., Chen, Y. H., Tobita, K., Downes, M. R., Wood, M. R., Sun, L., Li, X. H., Xia, Y., Ding, N., Spaeth, J. M., Moresco, E. M. Y., et al. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet Proceedings of the National Academy of Sciences of the United States of America  2011 108:19678-19682  DOI:10.1073/pnas.1117835108  PMID:22106289  PMCID:PMC3241770
  • Brandl, K., Sun, L., Neppl, C., Siggs, O. M., Le Gall, S. M., Tomisato, W., Li, X. H., Du, X., Maennel, D. N., Blobel, C. P., Beutler, B. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands Proceedings of the National Academy of Sciences of the United States of America  2010 107:19967-19972  DOI:10.1073/pnas.1014669107  PMID:21041656  PMCID:PMC2993336
  • Blasius, A. L., Arnold, C. N., Georgel, P., Rutschmann, S., Xia, Y., Lin, P., Ross, C., Li, X. H., Smart, N. G., Beutler, B. Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells Proceedings of the National Academy of Sciences of the United States of America  2010 107:19973-19978  DOI:10.1073/pnas.1014051107  PMID:21045126  PMCID:PMC2993408
  • Li, X. H., Kamenecka, T. M., Cameron, M. D. Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile Drug Metabolism and Disposition  2010 38:1238-1245  DOI:10.1124/dmd.109.030361  PMID:20382753  PMCID:PMC3202369
  • Polter, A., Beurel, E., Yang, S. F., Garner, R., Song, L., Miller, C. A., Sweatt, J. D., McMahon, L., Bartolucci, A. A., Li, X. H., Jope, R. S. Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances Neuropsychopharmacology  2010 35:1761-1774  DOI:10.1038/npp.2010.43  PMID:20357757  PMCID:PMC2891528
  • Berger, M., Krebs, P., Crozat, K., Li, X. H., Croker, B. A., Siggs, O. M., Popkin, D., Du, X., Lawson, B. R., Theofilopoulos, A. N., Xia, Y., Khovananth, K., et al. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence Nature Immunology  2010 11:335-343  DOI:10.1038/ni.1847  PMID:20190759  PMCID:PMC2861894
  • Li, X. H., Kamenecka, T. M., Cameron, M. D. Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: Implications for pulmonary and hepatic toxicities Chemical Research in Toxicology  2009 22:1736-1742  DOI:10.1021/tx900256y  PMID:19803472
  • Li, X. H., He, Y. J., Ruiz, C. H., Koenig, M., Cameron, M. D. Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways Drug Metabolism and Disposition  2009 37:1242-1250  DOI:10.1124/dmd.108.025932  PMID:19282395  PMCID:PMC3202349
  • Brandl, K., Rutschmann, S., Li, X. H., Du, X., Xiao, N. M., Schnabl, B., Brenner, D. A., Beutler, B. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response Proceedings of the National Academy of Sciences of the United States of America  2009 106:3300-3305  DOI:10.1073/pnas.0813036106  PMID:19202076  PMCID:PMC2651297
  • Liu, E. B., Li, X. H., Yan, F., Zhao, Q. P., Wu, X. H. Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation Journal of Biological Chemistry  2004 279:17283-17288  DOI:10.1074/jbc.C300549200  PMID:15004027
  • Li, X. H., Zhao, Q. P., Liao, R., Sun, P. Q., Wu, X. H. The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation Journal of Biological Chemistry  2003 278:30854-30858  DOI:10.1074/jbc.C300251200  PMID:12840033