recent publications
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academic article
- Li, X. H., Song, X. Y., Kamenecka, T. M., Cameron, M. D. Discovery of a highly selective CYP3A4 inhibitor suitable for reaction phenotyping studies and differentiation of CYP3A4 and CYP3A5 Drug Metabolism and Disposition 2012 40:1803-1809 DOI:10.1124/dmd.112.046144 PMID:22696420 PMCID:PMC3422543
- Arnold, C. N., Pirie, E., Dosenovic, P., McInerney, G. M., Xia, Y., Wang, N., Li, X. H., Siggs, O. M., Hedestam, G. B. K., Beutler, B. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity Proceedings of the National Academy of Sciences of the United States of America 2012 109:12286-12293 DOI:10.1073/pnas.1209134109 PMID:22761313 PMCID:PMC3411946
- Brandl, K., Tomisato, W., Li, X. H., Neppl, C., Pirie, E., Falk, W., Xia, Y., Moresco, E. M. Y., Baccala, R., Theofilopoulos, A. N., Schnabl, B., Beutler, B. Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice Proceedings of the National Academy of Sciences of the United States of America 2012 109:12650-12655 DOI:10.1073/pnas.1210366109 PMID:22802641 PMCID:PMC3412000
- Siggs, O. M., Xiao, N. M., Wang, Y., Shi, H. X., Tomisato, W., Li, X. H., Xia, Y., Beutler, B. IRhom2 is required for the secretion of mouse TNFα Blood 2012 119:5769-5771 DOI:10.1182/blood-2012-03-417949 PMID:22550345 PMCID:PMC3382936
- Li, X. H., Cameron, M. D. Potential role of a quetiapine metabolite in quetiapine-induced neutropenia and agranulocytosis Chemical Research in Toxicology 2012 25:1004-1011 DOI:10.1021/tx2005635 PMID:22506851
- Song, X. Y., Li, X. H., Ruiz, C. H., Yin, Y., Feng, Y., Kamenecka, T. M., Cameron, M. D. Imidazopyridines as selective CYP3A4 inhibitors Bioorganic & Medicinal Chemistry Letters 2012 22:1611-1614 DOI:10.1016/j.bmcl.2011.12.125 PMID:22264486 PMCID:PMC4481867
- Siggs, O. M., Li, X. H., Xia, Y., Beutler, B. ZBTB1 is a determinant of lymphoid development Journal of Experimental Medicine 2012 209:19-27 DOI:10.1084/jem.20112084 PMID:22201126 PMCID:PMC3260866
- Krebs, P., Fan, W. W., Chen, Y. H., Tobita, K., Downes, M. R., Wood, M. R., Sun, L., Li, X. H., Xia, Y., Ding, N., Spaeth, J. M., Moresco, E. M. Y., et al. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet Proceedings of the National Academy of Sciences of the United States of America 2011 108:19678-19682 DOI:10.1073/pnas.1117835108 PMID:22106289 PMCID:PMC3241770
- Brandl, K., Sun, L., Neppl, C., Siggs, O. M., Le Gall, S. M., Tomisato, W., Li, X. H., Du, X., Maennel, D. N., Blobel, C. P., Beutler, B. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands Proceedings of the National Academy of Sciences of the United States of America 2010 107:19967-19972 DOI:10.1073/pnas.1014669107 PMID:21041656 PMCID:PMC2993336
- Blasius, A. L., Arnold, C. N., Georgel, P., Rutschmann, S., Xia, Y., Lin, P., Ross, C., Li, X. H., Smart, N. G., Beutler, B. Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells Proceedings of the National Academy of Sciences of the United States of America 2010 107:19973-19978 DOI:10.1073/pnas.1014051107 PMID:21045126 PMCID:PMC2993408
- Li, X. H., Kamenecka, T. M., Cameron, M. D. Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile Drug Metabolism and Disposition 2010 38:1238-1245 DOI:10.1124/dmd.109.030361 PMID:20382753 PMCID:PMC3202369
- Polter, A., Beurel, E., Yang, S. F., Garner, R., Song, L., Miller, C. A., Sweatt, J. D., McMahon, L., Bartolucci, A. A., Li, X. H., Jope, R. S. Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances Neuropsychopharmacology 2010 35:1761-1774 DOI:10.1038/npp.2010.43 PMID:20357757 PMCID:PMC2891528
- Berger, M., Krebs, P., Crozat, K., Li, X. H., Croker, B. A., Siggs, O. M., Popkin, D., Du, X., Lawson, B. R., Theofilopoulos, A. N., Xia, Y., Khovananth, K., et al. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence Nature Immunology 2010 11:335-343 DOI:10.1038/ni.1847 PMID:20190759 PMCID:PMC2861894
- Li, X. H., Kamenecka, T. M., Cameron, M. D. Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: Implications for pulmonary and hepatic toxicities Chemical Research in Toxicology 2009 22:1736-1742 DOI:10.1021/tx900256y PMID:19803472
- Li, X. H., He, Y. J., Ruiz, C. H., Koenig, M., Cameron, M. D. Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways Drug Metabolism and Disposition 2009 37:1242-1250 DOI:10.1124/dmd.108.025932 PMID:19282395 PMCID:PMC3202349
- Brandl, K., Rutschmann, S., Li, X. H., Du, X., Xiao, N. M., Schnabl, B., Brenner, D. A., Beutler, B. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response Proceedings of the National Academy of Sciences of the United States of America 2009 106:3300-3305 DOI:10.1073/pnas.0813036106 PMID:19202076 PMCID:PMC2651297
- Liu, E. B., Li, X. H., Yan, F., Zhao, Q. P., Wu, X. H. Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation Journal of Biological Chemistry 2004 279:17283-17288 DOI:10.1074/jbc.C300549200 PMID:15004027
- Li, X. H., Zhao, Q. P., Liao, R., Sun, P. Q., Wu, X. H. The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation Journal of Biological Chemistry 2003 278:30854-30858 DOI:10.1074/jbc.C300251200 PMID:12840033