recent publications

• academic article

  • Joyce, M. G., Kanekiyo, M., Xu, L., Biertumpfel, C., Boyington, J. C., Moquin, S., Shi, W., Wu, X., Yang, Y., Yang, Z. Y., Zhang, B., Zheng, A., et al. Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04 Journal of Virology  2013 87:2294-2306  DOI:10.1128/jvi.02717-12  PMID:23236069  PMCID:PMC3571475
  • Wu, X. L., Zhou, T. Q., Zhu, J., Zhang, B. S., Georgiev, I., Wang, C., Chen, X. J., Longo, N. S., Louder, M., McKee, K., O'Dell, S., Perfetto, S., et al. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing Science  2011 333:1593-1602  DOI:10.1126/science.1207532  PMID:21835983  PMCID:PMC3516815
  • Liu, S. J., Yu, Z. H., Yu, X. A., Huang, S. X., Luo, Y. G., Wu, L., Shen, W. H., Yang, Z. Y., Wang, L. N., Gunawan, A. M., Chan, R. J., Shen, B., et al. Shp2 is a target of the immunosuppressant tautomycetin Chemistry & Biology  2011 18:101-110  DOI:10.1016/j.chembiol.2010.10.015  PMID:21276943  PMCID:PMC3034256
  • McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J. P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K. F., O'Dell, S., Patel, N., et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Nature  2011 480:336-343  DOI:10.1038/nature10696  PMID:22113616  PMCID:PMC3406929
  • Wu, X. L., Yang, Z. Y., Li, Y. X., Hogerkorp, C. M., Schief, W. R., Seaman, M. S., Zhou, T. Q., Schmidt, S. D., Wu, L., Xu, L., Longo, N. S., McKee, K., et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to hiv-1 Science  2010 329:856-861  DOI:10.1126/science.1187659  PMID:20616233  PMCID:PMC2965066
  • Ofek, G., McKee, K., Yang, Y. P., Yang, Z. Y., Skinner, J., Guenaga, F. J., Wyatt, R., Zwick, M. B., Nabel, G. J., Mascola, J. R., Kwong, P. D. Relationship between antibody 2f5 neutralization of hiv-1 and hydrophobicity of its heavy chain third complementarity-determining region Journal of Virology  2010 84:2955-2962  DOI:10.1128/jvi.02257-09  PMID:20042512  PMCID:PMC2826063
  • Zhou, T., Georgiev, I., Wu, X., Yang, Z. Y., Dai, K., Finzi, A., Kwon, Y. D., Scheid, J. F., Shi, W., Xu, L., Yang, Y., Zhu, J., et al. Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01 Science  2010 329:811-817  DOI:10.1126/science.1192819  PMID:20616231  PMCID:PMC2981354
  • Wu, L., Zhou, T. Q., Yang, Z. Y., Svehla, K., O'Dell, S., Louder, M. K., Xu, L., Mascola, J. R., Burton, D. R., Hoxie, J. A., Doms, R. W., Kwong, P. D., et al. Enhanced exposure of the cd4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain Journal of Virology  2009 83:5077-5086  DOI:10.1128/jvi.02600-08  PMID:19264769  PMCID:PMC2682083
  • Chen, L., Kwon, Y. D., Zhou, T. Q., Wu, X. L., O'Dell, S., Cavacini, L., Hessell, A. J., Pancera, M., Tang, M., Xu, L., Yang, Z. Y., Zhang, M. Y., et al. Structural basis of immune evasion at the site of cd4 attachment on hiv-1 gp120 Science  2009 326:1123-1127  DOI:10.1126/science.1175868  PMID:19965434  PMCID:PMC2862588
  • Wei, C. J., Xu, L., Kong, W. P., Shi, W., Canis, K., Stevens, J., Yang, Z. Y., Dell, A., Haslam, S. M., Wilson, I. A., Nabel, G. J. Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian h5n1 influenza virus Journal of Virology  2008 82:6200-6208  DOI:10.1128/jvi.00187-08  PMID:18417563  PMCID:PMC2447076
  • Urizar, N. L., Yang, Z. Y., Edenberg, H. J., Davis, R. L. Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance Journal of Neuroscience  2007 27:4541-4551  DOI:10.1523/jneurosci.0305-07.2007  PMID:17460067
  • Letvin, N. L., Mascola, J. R., Sun, Y., Gorgone, D. A., Buzby, A. P., Xu, L., Yang, Z. Y., Chakrabarti, B., Rao, S. S., Schmitz, J. E., Montefiori, D. C., Barker, B. R., et al. Preserved cd4(+) central memory t cells and survival in vaccinated siv-challenged monkeys Science  2006 312:1530-1533  DOI:10.1126/science.1124226  PMID:16763152  PMCID:PMC2365913
  • Chakrabarti, B. K., Ling, X., Yang, Z. Y., Montefiori, D. C., Panet, A., Kong, W. P., Welcher, B., Louder, M. K., Mascola, J. R., Nabel, G. J. Expanded breadth of virus neutralization after immunization with a multiclade envelope hiv vaccine candidate Vaccine  2005 23:3434-3445  DOI:10.1016/j.vaccine.2005.01.099  PMID:15837367
  • Yang, Z. Y., Edenberg, H. J., Davis, R. L. Isolation of mRNA from specific tissues of Drosophila by mRNA tagging Nucleic Acids Research  2005 33:e148  DOI:10.1093/nar/gni149  PMID:16204451  PMCID:PMC1243647
  • Mascola, J. R., Sambor, A., Beaudry, K., Santra, S., Welcher, B., Louder, M. K., VanCott, T. C., Huang, Y., Chakrabarti, B. K., Kong, W. P., Yang, Z. Y., Xu, L., et al. Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins Journal of Virology  2005 79:771-779  DOI:10.1128/jvi.79.2.771-779.2005  PMID:15613305
  • Santra, S., Seaman, M. S., Xu, L., Barouch, D. H., Lord, C. I., Lifton, M. A., Gorgone, D. A., Beaudry, K. R., Svehla, K., Welcher, B., Chakrabarti, B. K., Huang, Y., et al. Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates Journal of Virology  2005 79:6516-6522  DOI:10.1128/jvi.79.10.6516-6522.2005  PMID:15858035
  • Letvin, N. L., Huang, Y., Chakrabarti, B. K., Xu, L., Seaman, M. S., Beaudry, K., Korioth-Schmitz, B., Yu, F., Rohne, D., Martin, K. L., Miura, A., Kong, W. P., et al. Heterologous envelope immunogens contribute to aids vaccine protection in rhesus monkeys Journal of Virology  2004 78:7490-7497  DOI:10.1128/jvi.78.14.7490-7497.2004  PMID:15220422
  • Yang, Z. Y., Chakrabarti, B. K., Xu, L., Welcher, B., Kong, W. P., Leung, K., Panet, A., Mascola, J. R., Nabel, G. J. Selective modification of variable loops alters tropism and enhances immunogenicity of human immunodeficiency virus type 1 envelope Journal of Virology  2004 78:4029-4036  DOI:10.1128/jvi.78.8.4029-4036.2004  PMID:15047819
  • Kong, W. P., Huang, Y., Yang, Z. Y., Chakrabarti, B. K., Moodie, Z., Nabel, G. J. Immunogenicity of multiple gene and clade human immunodeficiency virus type 1 DNA vaccines Journal of Virology  2003 77:12764-12772  DOI:10.1128/jvi.77.23.12764-12772.2003  PMID:14610198
  • Baig, J., Levy, D. B., McKay, P. F., Schmitz, J. E., Santra, S., Subbramanian, R. A., Kuroda, M. J., Lifton, M. A., Gorgone, D. A., Wyatt, L. S., Moss, B., Huang, Y., et al. Elicitation of simian immunodeficiency virus-specific cytotoxic t lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination Journal of Virology  2002 76:11484-11490  DOI:10.1128/jvi.76.22.11484-11490.2002  PMID:12388710
  • Chakrabarti, B. K., Kong, W., Wu, B., Yang, Z. Y., Friborg, J., Ling, X., King, S. R., Montefiori, D. C., Nabel, G. J. Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization Journal of Virology  2002 76:5357-5368  DOI:10.1128/jvi.76.11.5357-5368.2002  PMID:11991964