recent publications

• academic article

  • Chang, M. R., He, Y., Khan, T. M., Kuruvilla, D. S., Garcia-Ordonez, R., Corzo, C. A., Unger, T. J., White, D. W., Khan, S., Lin, L., Cameron, M. D., Kamenecka, T. M., et al. Antiobesity effect of a small molecule repressor of RORγ Molecular Pharmacology  2015 88:48-56  DOI:10.1124/mol.114.097485  PMID:25904554  PMCID:PMC4468634
  • Corzo, C. A., Mari, Y., Chang, M. R., Khan, T., Kuruvilla, D., Nuhant, P., Kumar, N., West, G. M., Duckett, D. R., Roush, W. R., Griffin, P. R. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1 Molecular Pharmacology  2015 87:296-304  DOI:10.1124/mol.114.095554  PMID:25473120  PMCID:PMC4293447
  • Chang, M. R., Lyda, B., Kamenecka, T. M., Griffin, P. R. Pharmacologic repression of retinoic acid receptor-related orphan nuclear receptor gamma is therapeutic in the collagen-induced arthritis experimental model Arthritis & Rheumatology  2014 66:579-588  DOI:10.1002/art.38272  PMID:24574218  PMCID:PMC4474185
  • Marciano, D. P., Chang, M. R., Corzo, C. A., Goswami, D., Lam, V. Q., Pascal, B. D., Griffin, P. R. The therapeutic potential of nuclear receptor modulators for treatment of metabolic disorders: PPARγ, RORs, and Rev-erbs Cell Metabolism  2014 19:193-208  DOI:10.1016/j.cmet.2013.12.009  PMID:24440037
  • Chang, M. R., Rosen, H., Griffin, P. R. RORs in autoimmune disease Current Topics in Microbiology and Immunology  2014 378:171-182  DOI:10.1007/978-3-319-05879-5_8  PMID:24728598
  • Kamenecka, T. M., Lyda, B., Chang, M. R., Griffin, P. R. Synthetic modulators of the retinoic acid receptor-related orphan receptors MedChemComm  2013 4:764-776  DOI:10.1039/c3md00005b
  • Kumar, N., Lyda, B., Chang, M. R., Lauer, J. L., Solt, L. A., Burris, T. P., Kamenecka, T. M., Griffin, P. R. Identification of SR2211: a potent synthetic ROR gamma-selective modulator ACS Chemical Biology  2012 7:672-677  DOI:10.1021/cb200496y  PMID:22292739  PMCID:PMC3331898
  • Hughes, T. S., Chalmers, M. J., Novick, S., Kuruvilla, D. S., Chang, M. R., Kamenecka, T. M., Rance, M., Johnson, B. A., Burris, T. P., Griffin, P. R., Kojetin, D. J. Ligand and receptor dynamics contribute to the mechanism of graded PPAR gamma agonism Structure  2012 20:139-150  DOI:10.1016/j.str.2011.10.018  PMID:22244763  PMCID:PMC3278220