recent publications

• academic article

  • Harbut, M. B., Vilcheze, C., Luo, X., Hensler, M. E., Guo, H., Yang, B., Chatterjee, A. K., Nizet, V., Jacobs Jr., W. R., Schultz, P. G., Wang, F. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis Proceedings of the National Academy of Sciences of the United States of America  2015 112:4453-4458  DOI:10.1073/pnas.1504022112  PMID:25831516  PMCID:PMC4394260
  • Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A., Zlokovic, B. V. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Journal of Neuroscience  2013 33:6181-6190  DOI:10.1523/jneurosci.4491-12.2013  PMID:23554499
  • Yu, Y., Guo, H., Zhang, Q., Duan, L. A., Ding, Y., Liao, R. J., Lei, C., Shen, B., Liu, W. Nosa catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptide Journal of the American Chemical Society  2010 132:16324-16326  DOI:10.1021/ja106571g  PMID:21047073  PMCID:PMC2990472
  • Guo, H., Wang, Y. M., Singh, I., Liu, D., Fernandez, J. A., Griffin, J. H., Chow, N., Zlokovic, B. V. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity Journal of Neurochemistry  2009 109:116-124  DOI:10.1111/j.1471-4159.2009.05921.x  PMID:19166505  PMCID:PMC2692505
  • Guo, H., Singh, I., Wang, Y. M., Deane, R., Barrett, T., Fernandez, J. A., Chow, N., Griffin, J. H., Zlokovic, B. V. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity European Journal of Neuroscience  2009 29:1119-1130  DOI:10.1111/j.1460-9568.2009.06664.x  PMID:19302148  PMCID:PMC2692517
  • Griffin, J. H., Fernandez, J. A., Mosnier, L. O., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. The promise of protein C Blood Cells Molecules and Diseases  2006 36:211-216  DOI:10.1016/j,bcmd.2005.12.023  PMID:16464623
  • Liu, D., Cheng, T., Guo, H., Fernandez, J. A., Griffin, J. H., Song, X. M., Zlokovic, B. V. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C Nature Medicine  2004 10:1379-1383  DOI:10.1038/nm1122  PMID:15516929
  • Griffin, J. H., Fernandez, J. A., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. Activated protein C and ischemic stroke Critical Care Medicine  2004 32:S247-S253  DOI:10.1097/01.cmm.0000126127.87484.2b  PMID:15118526
  • Guo, H., Liu, D., Gelbard, H., Cheng, T., Insalaco, R., Fernandez, J. A., Griffin, J. H., Zlokovic, B. V. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 Neuron  2004 41:563-572  DOI:10.1016/s0896-6273(04)00019-4  PMID:14980205
  • Liu, D., Guo, H., Griffin, J. H., Fernandez, J. A., Zlokovic, B. V. Protein S confers neuronal protection during ischemic/hypoxic injury in mice Circulation  2003 107:1791-1796  DOI:10.1161/01.cir.0000058460.34453.5a  PMID:12665496