recent publications
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academic article
- Ma, M., Rateb, M. E., Teng, Q., Yang, D., Rudolf, J. D., Zhu, X., Huang, Y., Zhao, L. X., Jiang, Y., Li, X., Rader, C., Duan, Y., et al. Angucyclines and angucyclinones from streptomyces sp. CB01913 featuring C-ring cleavage and expansion Journal of Natural Products 2015 78:2471-2480 DOI:10.1021/acs.jnatprod.5b00601 PMID:26335269 PMCID:PMC4845661
- Huang, S. X., Yun, B. S., Ma, M., Basu, H. S., Church, D. R., Ingenhorst, G., Huang, Y., Yang, D., Lohman, J. R., Tang, G. L., Ju, J., Liu, T., et al. Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species Proceedings of the National Academy of Sciences of the United States of America 2015 112:8278-8283 DOI:10.1073/pnas.1506761112 PMID:26056295 PMCID:PMC4500275
- Barbian, H. J., Decker, J. M., Bibollet-Ruche, F., Galimidi, R. P., West Jr., A. P., Learn, G. H., Parrish, N. F., Iyer, S. S., Li, Y., Pace, C. S., Song, R., Huang, Y., et al. Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas MBio 2015 6:e00296 DOI:10.1128/mBio.00296-15 PMID:25900654 PMCID:PMC4453581
- Sadat, M. A., Moir, S., Chun, T. W., Lusso, P., Kaplan, G., Wolfe, L., Memoli, M. J., He, M., Vega, H., Kim, L. J. Y., Huang, Y., Hussein, N., et al. Glycosylation, hypogammaglobulinemia, and resistance to viral infections New England Journal of Medicine 2014 370:1615-1625 DOI:10.1056/NEJMoa1302846 PMID:24716661 PMCID:PMC4066413
- Hindra, Huang, T., Yang, D., Rudolf, J. D., Xie, P., Xie, G., Teng, Q., Lohman, J. R., Zhu, X., Huang, Y., Zhao, L. X., Jiang, Y., et al. Strain prioritization for natural product discovery by a high-throughput real-time PCR method Journal of Natural Products 2014 77:2296-2303 DOI:10.1021/np5006168 PMID:25238028 PMCID:PMC4208669
- Predeus, A. V., Gopalakrishnan, S., Huang, Y., Tang, J., Feeney, A. J., Oltz, E. M., Artyomov, M. N. Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain loci Journal of Immunology 2014 192:1064-1070 DOI:10.4049/jimmunol.1302800 PMID:24353267 PMCID:PMC4096788
- Kelley, R. K., Nimeiri, H. S., Munster, P. N., Vergo, M. T., Huang, Y., Li, C. M., Hwang, J., Mulcahy, M. F., Yeh, B. M., Kuhn, P., Luttgen, M. S., Grabowsky, J. A., et al. Temsirolimus combined with sorafenib in hepatocellular carcinoma: A phase I dose-finding trial with pharmacokinetic and biomarker correlates Annals of Oncology 2013 24:1900-1907 DOI:10.1093/annonc/mdt109 PMID:23519998 PMCID:PMC3690907
- Gopalakrishnan, S., Majumder, K., Predeus, A., Huang, Y., Koues, O. I., Verma-Gaur, J., Loguercio, S., Su, A. I., Feeney, A. J., Artyomov, M. N., Oltz, E. M. Unifying model for molecular determinants of the preselection Vβ repertoire Proceedings of the National Academy of Sciences of the United States of America 2013 110:E3206-E3215 DOI:10.1073/pnas.1304048110 PMID:23918392 PMCID:PMC3752219
- Huang, Y., Huang, S. X., Ju, J. H., Tang, G. L., Liu, T., Shen, B. Characterization of the inmklm genes unveiling key intermediates for beta-alkylation in leinamycin biosynthesis Organic Letters 2011 13:498-501 DOI:10.1021/ol102838y PMID:21192727 PMCID:PMC3074603
- Astle, J. M., Simpson, L. S., Huang, Y., Reddy, M. M., Wilson, R., Connell, S., Wilson, J., Kodadek, T. Seamless bead to microarray screening: Rapid identification of the highest affinity protein ligands from large combinatorial libraries Chemistry & Biology 2010 17:38-45 DOI:10.1016/j.chembiol.2009.12.015 PMID:20142039 PMCID:PMC2905650
- Liu, T., Huang, Y., Shen, B. Bifunctional acyltransferase/decarboxylase lnmk as the missing link for beta-alkylation in polyketide biosynthesis Journal of the American Chemical Society 2009 131:6900-6901 DOI:10.1021/ja9012134 PMID:19405532 PMCID:PMC2697816
- Huang, Y., Wendt-Pienkowski, E., Shen, B. A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from streptomyces griseus Journal of Biological Chemistry 2006 281:29660-29668 DOI:10.1074/jbc.M604895200 PMID:16895912
- Tilley, R. E., Pedersen, B., Pawlinski, R., Sato, Y., Erlich, J. H., Shen, Y. C., Day, S., Huang, Y., Eitzman, D. T., Boisvert, W. A., Curtiss, L. K., Fay, W. P., et al. Atherosclerosis in mice is not affected by a reduction in tissue factor expression Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26:555-562 DOI:10.1161/01.ATV.0000202028.62414.3c PMID:16385085
- Wendt-Pienkowski, E., Huang, Y., Zhang, J., Li, B. S., Jiang, H., Kwon, H. J., Hutchinson, C. R., Shen, B. Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from streptomyces griseus Journal of the American Chemical Society 2005 127:16442-16452 DOI:10.1021/ja054376u PMID:16305230
- Savonitto, S., Cohen, M. G., Politi, A., Hudson, M. P., Kong, D. F., Huang, Y., Pieper, K. S., Mauri, F., Wagner, G. S., Califf, R. M., Topol, E. J., Granger, C. B. Extent of st-segment depression and cardiac events in non-st-segment elevation acute coronary syndromes European Heart Journal 2005 26:2106-2113 DOI:10.1093/eurheartj/ehi395 PMID:15987706
- Seaman, M. S., Xu, L., Beaudry, K., Martin, K. L., Beddall, M. H., Miura, A., Sambor, A., Chakrabarti, B. K., Huang, Y., Bailer, R., Koup, R. A., Mascola, J. R., et al. Multiclade human immunodeficiency virus type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys Journal of Virology 2005 79:2956-2963 DOI:10.1128/jvi.79.5.2956-2963.2005 PMID:15709015
- Mascola, J. R., Sambor, A., Beaudry, K., Santra, S., Welcher, B., Louder, M. K., VanCott, T. C., Huang, Y., Chakrabarti, B. K., Kong, W. P., Yang, Z. Y., Xu, L., et al. Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins Journal of Virology 2005 79:771-779 DOI:10.1128/jvi.79.2.771-779.2005 PMID:15613305
- Santra, S., Seaman, M. S., Xu, L., Barouch, D. H., Lord, C. I., Lifton, M. A., Gorgone, D. A., Beaudry, K. R., Svehla, K., Welcher, B., Chakrabarti, B. K., Huang, Y., et al. Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates Journal of Virology 2005 79:6516-6522 DOI:10.1128/jvi.79.10.6516-6522.2005 PMID:15858035
- Letvin, N. L., Huang, Y., Chakrabarti, B. K., Xu, L., Seaman, M. S., Beaudry, K., Korioth-Schmitz, B., Yu, F., Rohne, D., Martin, K. L., Miura, A., Kong, W. P., et al. Heterologous envelope immunogens contribute to aids vaccine protection in rhesus monkeys Journal of Virology 2004 78:7490-7497 DOI:10.1128/jvi.78.14.7490-7497.2004 PMID:15220422
- Lemiale, F., Kong, W. P., Akyurek, L. M., Ling, X., Huang, Y., Chakrabarti, B. K., Eckhaus, M., Nabel, G. J. Enhanced mucosal immunoglobulin a response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system Journal of Virology 2003 77:10078-10087 DOI:10.1128/jvi.77.18.10078-10087.2003 PMID:12941918
- Kong, W. P., Huang, Y., Yang, Z. Y., Chakrabarti, B. K., Moodie, Z., Nabel, G. J. Immunogenicity of multiple gene and clade human immunodeficiency virus type 1 DNA vaccines Journal of Virology 2003 77:12764-12772 DOI:10.1128/jvi.77.23.12764-12772.2003 PMID:14610198
- Baig, J., Levy, D. B., McKay, P. F., Schmitz, J. E., Santra, S., Subbramanian, R. A., Kuroda, M. J., Lifton, M. A., Gorgone, D. A., Wyatt, L. S., Moss, B., Huang, Y., et al. Elicitation of simian immunodeficiency virus-specific cytotoxic t lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination Journal of Virology 2002 76:11484-11490 DOI:10.1128/jvi.76.22.11484-11490.2002 PMID:12388710
- Al-Khatib, S. M., Granger, C. B., Huang, Y., Lee, K. L., Califf, R. M., Simoons, M. L., Armstrong, P. W., Van de Werf, F., White, H. D., Simes, R. J., Moliterno, D. J., Topol, E. J., et al. Sustained ventricular arrhythmias among patients with acute coronary syndromes with no st-segment elevation - incidence, predictors, and outcomes Circulation 2002 106:309-312 DOI:10.1161/01.cir.0000022692.49934.e3 PMID:12119245