Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Antinarcotic effects of the standardized ginseng extract g115 on morphine

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Kim, H. S.
  • Jang, Choon-Gon
  • Lee, M. K.

publication date

  • April 1990

journal

  • Planta Medica  Journal

abstract

  • The study was undertaken to determine the antagonism of morphine analgesia by the standardized ginseng extract G115 from Panax ginseng, the inhibitory effects of orally administered G115 on the development of morphine-induced tolerance and physical dependence, the hepatic glutathione levels, the inhibitory effects of intraperitoneally administered G115 on the dopamine receptor supersensitivity, and the reverse tolerance to the locomotor accelerating effect of morphine. G115 significantly inhibits the development of morphine-induced tolerance and physical dependence, the hepatic glutathione level decrease induced by morphine multiple injections, the development of morphine-induced dopamine receptor supersensitivity, and reverse tolerance to the locomotor accelerating effect of morphine. It did not, however, antagonize morphine analgesia.

subject areas

  • Animals
  • Drug Tolerance
  • Glutathione
  • Liver
  • Male
  • Mice
  • Mice, Inbred ICR
  • Morphine
  • Naloxone
  • Panax
  • Plant Extracts
  • Plants, Medicinal
  • Receptors, Dopamine
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0032-0943

Digital Object Identifier (DOI)

  • 10.1055/s-2006-960915

PubMed ID

  • 2353061
scroll to property group menus

Additional Document Info

start page

  • 158

end page

  • 163

volume

  • 56

issue

  • 2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support