recent publications
-
academic article
- McCall, L. I., El Aroussi, A., Choi, J. Y., Vieira, D. F., De Muylder, G., Johnston, J. B., Chen, S., Kellar, D., Siqueira-Neto, J. L., Roush, W. R., Podust, L. M., McKerrow, J. H. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase PLoS Neglected Tropical Diseases 2015 9 DOI:10.1371/journal.pntd.0003588 PMID:25768284 PMCID:PMC4359151
- Vieira, D. F., Choi, J. Y., Calvet, C. M., Siqueira-Neto, J. L., Johnston, J. B., Kellar, D., Gut, J., Cameron, M. D., McKerrow, J. H., Roush, W. R., Podust, L. M. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51 Journal of Medicinal Chemistry 2014 57:10162-10175 DOI:10.1021/jm501568b PMID:25393646 PMCID:PMC4266343
- Choi, J. Y., Podust, L. M., Roush, W. R. Drug strategies targeting CYP51 in neglected tropical diseases Chemical Reviews 2014 114:11242-11271 DOI:10.1021/cr5003134 PMID:25337991 PMCID:PMC4254036
- Calvet, C. M., Vieira, D. F., Choi, J. Y., Kellar, D., Cameron, M. D., Siqueira-Neto, J. L., Gut, J., Johnston, J. B., Lin, L., Khan, S., McKerrow, J. H., Roush, W. R., et al. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency Journal of Medicinal Chemistry 2014 57:6989-7005 DOI:10.1021/jm500448u PMID:25101801 PMCID:PMC4148169
- Vieira, D. F., Choi, J. Y., Roush, W. R., Podust, L. M. Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives ChemBioChem 2014 15:1111-1120 DOI:10.1002/cbic.201402027 PMID:24771705 PMCID:PMC4091728
- Choi, J. Y., Calvet, C. M., Vieira, D. F., Gunatilleke, S. S., Cameron, M. D., McKerrow, J. H., Podust, L. M., Roush, W. R. R-configuration of 4-aminopyridyl-based inhibitors of CYP51 confers superior efficacy against Trypanosoma cruzi ACS Medicinal Chemistry Letters 2014 5:434-439 DOI:10.1021/ml500010m PMID:24900854 PMCID:PMC4027616
- Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., Minong, D., Spicer, T. P. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Journal of Medicinal Chemistry 2014 57:9598-9611 DOI:10.1021/jm501284e PMID:25330343 PMCID:PMC4255739
- Choi, J. Y., Calvet, C. M., Gunatilleke, S. S., Ruiz, C., Cameron, M. D., McKerrow, J. H., Podust, L. M., Roush, W. R. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents Journal of Medicinal Chemistry 2013 56:7651-7668 DOI:10.1021/jm401067s PMID:24079662 PMCID:PMC3864028
- Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schurer, S., Chen, W. M., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Bioorganic & Medicinal Chemistry Letters 2013 23:4374-4380 DOI:10.1016/j.bmcl.2013.05.075 PMID:23787102 PMCID:PMC3783656
- Choi, J. Y., Plummer, M. S., Starr, J., Desbonnet, C. R., Soutter, H., Chang, J., Miller, J. R., Dillman, K., Miller, A. A., Roush, W. R. Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation Journal of Medicinal Chemistry 2012 55:852-870 DOI:10.1021/jm201349f PMID:22243413 PMCID:PMC3306445
- Lee, Y., Choi, J. Y., Fu, H., Harvey, C., Ravindran, S., Roush, W. R., Boothroyd, J. C., Khosla, C. Chemistry and biology of macrolide antiparasitic agents Journal of Medicinal Chemistry 2011 54:2792-2804 DOI:10.1021/jm101593u PMID:21428405 PMCID:PMC3085955