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Choi, J. Y.

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    • McCall, L. I., El Aroussi, A., Choi, J. Y., Vieira, D. F., De Muylder, G., Johnston, J. B., Chen, S., Kellar, D., Siqueira-Neto, J. L., Roush, W. R., Podust, L. M., McKerrow, J. H. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase PLoS Neglected Tropical Diseases  2015 9  DOI:10.1371/journal.pntd.0003588  PMID:25768284  PMCID:PMC4359151
    • Vieira, D. F., Choi, J. Y., Calvet, C. M., Siqueira-Neto, J. L., Johnston, J. B., Kellar, D., Gut, J., Cameron, M. D., McKerrow, J. H., Roush, W. R., Podust, L. M. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51 Journal of Medicinal Chemistry  2014 57:10162-10175  DOI:10.1021/jm501568b  PMID:25393646  PMCID:PMC4266343
    • Choi, J. Y., Podust, L. M., Roush, W. R. Drug strategies targeting CYP51 in neglected tropical diseases Chemical Reviews  2014 114:11242-11271  DOI:10.1021/cr5003134  PMID:25337991  PMCID:PMC4254036
    • Calvet, C. M., Vieira, D. F., Choi, J. Y., Kellar, D., Cameron, M. D., Siqueira-Neto, J. L., Gut, J., Johnston, J. B., Lin, L., Khan, S., McKerrow, J. H., Roush, W. R., et al. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency Journal of Medicinal Chemistry  2014 57:6989-7005  DOI:10.1021/jm500448u  PMID:25101801  PMCID:PMC4148169
    • Vieira, D. F., Choi, J. Y., Roush, W. R., Podust, L. M. Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives ChemBioChem  2014 15:1111-1120  DOI:10.1002/cbic.201402027  PMID:24771705  PMCID:PMC4091728
    • Choi, J. Y., Calvet, C. M., Vieira, D. F., Gunatilleke, S. S., Cameron, M. D., McKerrow, J. H., Podust, L. M., Roush, W. R. R-configuration of 4-aminopyridyl-based inhibitors of CYP51 confers superior efficacy against Trypanosoma cruzi ACS Medicinal Chemistry Letters  2014 5:434-439  DOI:10.1021/ml500010m  PMID:24900854  PMCID:PMC4027616
    • Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., Minong, D., Spicer, T. P. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Journal of Medicinal Chemistry  2014 57:9598-9611  DOI:10.1021/jm501284e  PMID:25330343  PMCID:PMC4255739
    • Choi, J. Y., Calvet, C. M., Gunatilleke, S. S., Ruiz, C., Cameron, M. D., McKerrow, J. H., Podust, L. M., Roush, W. R. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents Journal of Medicinal Chemistry  2013 56:7651-7668  DOI:10.1021/jm401067s  PMID:24079662  PMCID:PMC3864028
    • Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schurer, S., Chen, W. M., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Bioorganic & Medicinal Chemistry Letters  2013 23:4374-4380  DOI:10.1016/j.bmcl.2013.05.075  PMID:23787102  PMCID:PMC3783656
    • Choi, J. Y., Plummer, M. S., Starr, J., Desbonnet, C. R., Soutter, H., Chang, J., Miller, J. R., Dillman, K., Miller, A. A., Roush, W. R. Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation Journal of Medicinal Chemistry  2012 55:852-870  DOI:10.1021/jm201349f  PMID:22243413  PMCID:PMC3306445
    • Lee, Y., Choi, J. Y., Fu, H., Harvey, C., Ravindran, S., Roush, W. R., Boothroyd, J. C., Khosla, C. Chemistry and biology of macrolide antiparasitic agents Journal of Medicinal Chemistry  2011 54:2792-2804  DOI:10.1021/jm101593u  PMID:21428405  PMCID:PMC3085955

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