Total synthesis of the formamicin aglycon, formamicinone

Academic Article

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Overview

authors

• Savall, B. M.
• Blanchard, N.
• Roush, William

publication date

• 2003

journal

• Organic Letters  Journal

abstract

• [structure: see text] The total synthesis of formamicinone (2), the aglycone of formamicin (1), has been accomplished via the late-stage Suzuki cross-coupling of fragments 5 and 6, the macrolactonization of seco ester 14, and the Mukaiyama aldol reaction of aldehyde 3 and methyl ketone 4. An efficient and highly stereoselective second generation synthesis of vinyl iodide 6 is also described.

subject areas

• Anti-Bacterial Agents
• Macrolides
• Molecular Structure

Identity

International Standard Serial Number (ISSN)

• 1523-7060

Digital Object Identifier (DOI)

• 10.1021/ol027569k

PubMed ID

• 12556196

Additional Document Info

start page

• 377

end page

• 379

volume

• 5

issue

• 3