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Total synthesis of the formamicin aglycon, formamicinone

Academic Article
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Overview

authors

  • Savall, B. M.
  • Blanchard, N.
  • Roush, William

publication date

  • 2003

journal

  • Organic Letters  Journal

abstract

  • [structure: see text] The total synthesis of formamicinone (2), the aglycone of formamicin (1), has been accomplished via the late-stage Suzuki cross-coupling of fragments 5 and 6, the macrolactonization of seco ester 14, and the Mukaiyama aldol reaction of aldehyde 3 and methyl ketone 4. An efficient and highly stereoselective second generation synthesis of vinyl iodide 6 is also described.

subject areas

  • Anti-Bacterial Agents
  • Macrolides
  • Molecular Structure
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol027569k

PubMed ID

  • 12556196
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Additional Document Info

start page

  • 377

end page

  • 379

volume

  • 5

issue

  • 3

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