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Generation of activated protein-C during thrombolysis

Academic Article
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Overview

authors

  • Gruber, A.
  • Pal, A.
  • Kiss, R. G.
  • Sas, G.
  • Griffin, John

publication date

  • November 1993

journal

  • Lancet  Journal

abstract

  • The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 micrograms/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation--the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.

subject areas

  • Aged
  • Enzyme Activation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Protein C
  • Protein C Inhibitor
  • Streptokinase
  • Thrombolytic Therapy
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Identity

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/0140-6736(93)92364-y

PubMed ID

  • 7901587
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Additional Document Info

start page

  • 1275

end page

  • 1276

volume

  • 342

issue

  • 8882

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