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Elicitation of simian immunodeficiency virus-specific cytotoxic t lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination

Academic Article
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Overview

authors

  • Baig, J.
  • Levy, D. B.
  • McKay, P. F.
  • Schmitz, J. E.
  • Santra, S.
  • Subbramanian, R. A.
  • Kuroda, M. J.
  • Lifton, M. A.
  • Gorgone, D. A.
  • Wyatt, L. S.
  • Moss, B.
  • Huang, Y.
  • Chakrabarti, Bimal
  • Xu, L.
  • Kong, W. P.
  • Yang, Z. Y.
  • Mascola, J. R.
  • Nabel, G. J.
  • Carville, A.
  • Lackner, A. A.
  • Veazey, R. S.
  • Letvin, N. L.

publication date

  • November 2002

journal

  • Journal of Virology  Journal

abstract

  • Since most human immunodeficiency virus (HIV) infections are initiated following mucosal exposure to the virus, the anatomic containment or abortion of an HIV infection is likely to require vaccine-elicited cellular immune responses in those mucosal sites. Studying vaccine-elicited mucosal immune responses has been problematic because of the difficulties associated with sampling T lymphocytes from those anatomic compartments. In the present study, we demonstrate that mucosal cytotoxic T lymphocytes (CTL) specific for simian immunodeficiency virus (SIV) and simian HIV can be reproducibly sampled from intestinal mucosal tissue of rhesus monkeys obtained under endoscopic guidance. These lymphocytes recognize peptide-major histocompatibility complex class I complexes and express gamma interferon on exposure to peptide antigen. Interestingly, systemic immunization of monkeys with plasmid DNA immunogens followed by live recombinant attenuated poxviruses or adenoviruses with genes deleted elicits high-frequency SIV-specific CTL responses in these mucosal tissues. These studies therefore suggest that systemic delivery of potent HIV immunogens may suffice to elicit substantial mucosal CTL responses.

subject areas

  • AIDS Vaccines
  • Animals
  • Colon
  • HIV Infections
  • HIV-1
  • Humans
  • Intestinal Mucosa
  • Jejunum
  • Macaca mulatta
  • Simian Acquired Immunodeficiency Syndrome
  • Simian Immunodeficiency Virus
  • T-Lymphocytes, Cytotoxic
  • Vaccination
  • Vaccines, DNA
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Identity

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.76.22.11484-11490.2002

PubMed ID

  • 12388710
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Additional Document Info

start page

  • 11484

end page

  • 11490

volume

  • 76

issue

  • 22

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