recent publications

• academic article

  • Simeoni, F., Arvai, A., Bello, P., Gondeau, C., Hopfner, K. P., Neyroz, P., Heitz, F., Tainer, J., Divita, G. Biochemical characterization and crystal structure of a dim1 family associated protein: Dim2 Biochemistry  2005 44:11997-12008  DOI:10.1021/bi050427o  PMID:16142897
  • de Jager, M., Trujillo, K. M., Sung, P., Hopfner, K. P., Carney, J. P., Tainer, J. A., Connelly, J. C., Leach, D. R. F., Kanaar, R., Wyman, C. Differential arrangements of conserved building blocks among homologs of the rad50/mre11 DNA repair protein complex Journal of Molecular Biology  2004 339:937-949  DOI:10.1016/j.jmb.2004.04.014  PMID:15165861
  • Arthur, L. M., Gustausson, K., Hopfner, K. P., Carson, C. T., Stracker, T. H., Karcher, A., Felton, D., Weitzman, M. D., Tainer, J., Carney, J. P. Structural and functional analysis of mre11-3 Nucleic Acids Research  2004 32:1886-1893  DOI:10.1093/nar/gkh343  PMID:15047855  PMCID:PMC390353
  • Moncalian, G., Lengsfeld, B., Bhaskara, V., Hopfner, K. P., Karcher, A., Alden, E., Tainer, J. A., Paull, T. T. The rad50 signature motif: Essential to atp binding and biological function Journal of Molecular Biology  2004 335:937-951  DOI:10.1016/j.jmb.2003.11.026  PMID:14698290
  • Hopfner, K. P., Tainer, J. A. Rad50/smc proteins and abc transporters: Unifying concepts from high-resolution structures Current Opinion in Structural Biology  2003 13:249-255  DOI:10.1016/s0959-440x(03)00037-x  PMID:12727520
  • Hopfner, K. P., Craig, L., Moncalian, G., Zinkel, R. A., Usui, T., Owen, B. A. L., Karcher, A., Henderson, B., Bodmer, J. L., McMurray, C. T., Carney, J. P., Petrini, J. H. J., et al. The rad50 zinc-hook is a structure joining mre11 complexes in DNA recombination and repair Nature  2002 418:562-566  DOI:10.1038/nature00922  PMID:12152085
  • Hopfner, K. P., Putnam, C. D., Tainer, J. A. DNA double-strand break repair from head to tail Current Opinion in Structural Biology  2002 12:115-122  DOI:10.1016/s0959-440x(02)00297-x  PMID:11839498
  • Hopfner, K. P., Karcher, A., Craig, L., Woo, T. T., Carney, J. P., Tainer, J. A. Structural biochemistry and interaction architecture of the DNA double-strand break repair mre11 nuclease and rad50-atpase Cell  2001 105:473-485  DOI:10.1016/s0092-8674(01)00335-x  PMID:11371344
  • Hopfner, K. P., Tainer, J. A. DNA mismatch repair: The hands of a genome guardian Structure  2000 8:R237-R241  DOI:10.1016/s0969-2126(00)00545-1  PMID:11188699
  • Hopfner, K. P., Karcher, A., Shin, D., Fairley, C., Tainer, J. A., Carney, J. P. Mre11 and rad50 from pyrococcus furiosus: Cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine Journal of Bacteriology  2000 182:6036-6041  DOI:10.1128/jb.182.21.6036-6041.2000  PMID:11029422
  • Hopfner, K. P., Karcher, A., Shin, D. S., Craig, L., Arthur, L. M., Carney, J. P., Tainer, J. A. Structural biology of rad50 atpase: Atp-driven conformational control in DNA double-strand break repair and the abc-atpase superfamily Cell  2000 101:789-800  DOI:10.1016/s0092-8674(00)80890-9  PMID:10892749
  • Hopfner, K. P., Parikh, S. S., Tainer, J. A. Envisioning the fourth dimension of the genetic code: The structural biology of macromolecular recognition and conformational switching in DNA repair Cold Spring Harbor Symposia on Quantitative Biology  2000 65:113-126  DOI:10.1101/sqb.2000.65.113  PMID:12760026