Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

The cell tropism of human immunodeficiency virus type 1 determines the kinetics of plasma viremia in SCID mice reconstituted with human peripheral blood leukocytes

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Picchio, G. R.
  • Gulizia, R. J.
  • Wehrly, K.
  • Chesebro, B.
  • Mosier, Donald

publication date

  • 1998

journal

  • Journal of Virology  Journal

abstract

  • Most individuals infected with human immunodeficiency virus type 1 (HIV-1) initially harbor macrophage-tropic, non-syncytium-inducing (M-tropic, NSI) viruses that may evolve into T-cell-tropic, syncytium-inducing viruses (T-tropic, SI) after several years. The reasons for the more efficient transmission of M-tropic, NSI viruses and the slow evolution ofT-tropic, SI viruses remain unclear, although they may be linked to expression of appropriate chemokine coreceptors for virus entry. We have examined plasma viral RNA levels and the extent of CD4+ T-cell depletion in SCID mice reconstituted with human peripheral blood leukocytes following infection with M-tropic, dual-tropic, or T-tropic HIV-1 isolates. The cell tropism was found to determine the course of viremia, with M-tropic viruses producing sustained high viral RNA levels and sparing some CD4+ T cells, dual-tropic viruses producing a transient and lower viral RNA spike and extremely rapid depletion of CD4+ T cells, and T-tropic viruses causing similarly lower viral RNA levels and rapid-intermediate rates of CD4+ T-cell depletion. A single amino acid change in the V3 region of gp120 was sufficient to cause one isolate to switch from M-tropic to dual-tropic and acquire the ability to rapidly deplete all CD4+ T cells.

subject areas

  • Animals
  • CD4-Positive T-Lymphocytes
  • Disease Models, Animal
  • HIV Infections
  • HIV-1
  • Humans
  • Kinetics
  • Leukocytes, Mononuclear
  • Macrophages
  • Mice
  • Mice, SCID
  • RNA, Viral
  • Viremia
  • Virus Replication
scroll to property group menus

Identity

PubMed Central ID

  • PMC109493

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 9499054
scroll to property group menus

Additional Document Info

start page

  • 2002

end page

  • 2009

volume

  • 72

issue

  • 3

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support