Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Sinha, Subhash
  • Chen, Z. Y.
  • Huang, Z. Z.
  • Nakamaru-Ogiso, E.
  • Pietraszkiewicz, H.
  • Edelstein, M.
  • Valeriote, F.

publication date

  • 2008

journal

  • Journal of Medicinal Chemistry  Journal

abstract

  • A systematic analysis using 10 synthetic asimicin stereoisomers revealed that the stereochemistry of the bis-tetrahydrofuran core, including the tetrahydrofuran rings and the adjacent hydroxy functions, had significant effect on its cytotoxicity. Our findings set to rest the highly controversial perception that the stereochemistry of the tetrahydrofuran core has little effect on the activity, which is not true for its cytotoxic effect, and also reinforces the previous conclusion that asimicin is a highly potent anticancer compound.

subject areas

  • Animals
  • Cell Line, Tumor
  • Cell Proliferation
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Furans
  • Humans
  • Mice
  • Molecular Conformation
  • Stereoisomerism
  • Structure-Activity Relationship
scroll to property group menus

Identity

PubMed Central ID

  • PMC2670474

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm801028c

PubMed ID

  • 18975929
scroll to property group menus

Additional Document Info

start page

  • 7045

end page

  • 7048

volume

  • 51

issue

  • 22

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support