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Molecular analysis of the murine lupus-associated anti-self response - involvement of a large number of heavy and light chain variable region genes

Academic Article
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Overview

authors

  • Kofler, R.
  • Noonan, D. J.
  • Strohal, R.
  • Balderas, R. S.
  • Moller, N. P. H.
  • Dixon, F. J.
  • Theofilopoulos, Argyrios

publication date

  • January 1987

journal

  • European Journal of Immunology  Journal

abstract

  • The mRNA encoding heavy and light chains of a hybridoma-derived monoclonal IgM, kappa anti-immunoglobulin (rheumatoid factor) and an IgG3, kappa anti-histone autoantibody from systemic lupus erythematosus and arthritis-prone MRL/Mp-lpr/lpr mice have been molecularly cloned, and the nucleotide sequences corresponding to their variable regions have been determined. To investigate whether autoantibodies with specificities frequently observed in lupus disease might share common structural components, the sequences obtained in this study have been compared with those of a monoclonal MRL/Mp-lpr/lpr IgM, kappa anti-DNA autoantibody previously analyzed in our laboratory (J. Exp. Med. 1985. 161: 805). The 3 immunoglobulins employed different heavy chain variable region (VH) genes belonging to the large J588 VH gene family, kappa light chain variable region (V kappa) genes from 3 different V kappa groups, and different diversity and joining segments. Our findings suggest that murine lupus-associated autoantibodies of different specificities do not have genetic components in common to signal their self-reactive nature and are encoded by a large number of immunoglobulin gene elements.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Autoantibodies
  • Autoimmune Diseases
  • Base Sequence
  • Disease Models, Animal
  • Female
  • Gene Expression Regulation
  • Genes
  • Histones
  • Hybridomas
  • Immunoglobulin G
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Light Chains
  • Immunoglobulin M
  • Immunoglobulin kappa-Chains
  • Lupus Erythematosus, Systemic
  • Mice
  • Mice, Inbred Strains
  • Mice, Mutant Strains
  • RNA, Messenger
  • Rheumatoid Factor
  • Sequence Homology, Nucleic Acid
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Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.1830170116

PubMed ID

  • 3102255
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Additional Document Info

start page

  • 91

end page

  • 95

volume

  • 17

issue

  • 1

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