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Receptor editing and commitment in b lymphocytes

Academic Article
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Overview

authors

  • Hertz, M.
  • Nemazee, David

publication date

  • April 1998

journal

  • Current Opinion in Immunology  Journal

abstract

  • B cells that fail to pass a developmental checkpoint, either as immature or mature B cells, can be rescued by creating a new B cell antigen receptor through nested secondary immunoglobulin gene rearrangements, a process termed receptor editing. Tolerance-mediated receptor editing occurs in self-reactive immature bone marrow B cells, while peripheral receptor editing probably occurs in low-affinity B cells competing for antigen and for survival signals within the germinal center response.

subject areas

  • Animals
  • B-Lymphocytes
  • Cell Differentiation
  • DNA Nucleotidyltransferases
  • Gene Rearrangement
  • Humans
  • Immunoglobulins
  • Mice
  • Receptors, Antigen, B-Cell
  • Signal Transduction
  • VDJ Recombinases
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Identity

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/s0952-7915(98)80250-1

PubMed ID

  • 9602310
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Additional Document Info

start page

  • 208

end page

  • 213

volume

  • 10

issue

  • 2

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