recent publications

• academic article

  • Gokhin, D. S., Nowak, R. B., Khoory, J. A., de la Piedra, A., Ghiran, I. C., Fowler, V. M. Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane Molecular Biology of the Cell  2015 26:1699-1710  DOI:10.1091/mbc.E14-12-1583  PMID:25717184  PMCID:PMC4436781
  • Yuen, M., Sandaradura, S. A., Dowling, J. J., Kostyukova, A. S., Moroz, N., Quinlan, K. G., Lehtokari, V. L., Ravenscroft, G., Todd, E. J., Ceyhan-Birsoy, O., Gokhin, D. S., Maluenda, J., et al. Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy Journal of Clinical Investigation  2014 124:4693-4708  DOI:10.1172/jci75199  PMID:25250574
  • Gokhin, D. S., Dubuc, E. A., Lian, K. Q., Peters, L. L., Fowler, V. M. Alterations in thin filament length during postnatal skeletal muscle development and aging in mice Frontiers in Physiology  2014 5:375  DOI:10.3389/fphys.2014.00375  PMID:25324783  PMCID:PMC4178374
  • Lewis, R. A., Yamashiro, S., Gokhin, D. S., Fowler, V. M. Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3 Cytoskeleton  2014 71:395-411  DOI:10.1002/cm.21179  PMID:24922351  PMCID:PMC4347929
  • McKeown, C. R., Nowak, R. B., Gokhin, D. S., Fowler, V. M. Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo Developmental Dynamics  2014 243:800-817  DOI:10.1002/dvdy.24115  PMID:24500875  PMCID:PMC4031292
  • Yamashiro, S., Gokhin, D. S., Sui, Z., Bergeron, S. E., Rubenstein, P. A., Fowler, V. M. Differential actin-regulatory activities of Tropomodulin1 and Tropomodulin3 with diverse tropomyosin and actin isoforms Journal of Biological Chemistry  2014 289:11616-11629  DOI:10.1074/jbc.M114.555128  PMID:24644292  PMCID:PMC4002072
  • Ochala, J., Gokhin, D. S., Iwamoto, H., Fowler, V. M. Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers FASEB Journal  2014 28:408-415  DOI:10.1096/fj.13-239640  PMID:24072783  PMCID:PMC3868837
  • Gokhin, D. S., Fowler, V. M. A two-segment model for thin filament architecture in skeletal muscle Nature Reviews Molecular Cell Biology  2013 14:113-119  DOI:10.1038/nrm3510  PMID:23299957  PMCID:PMC3711620
  • Gokhin, D. S., Nowak, R. B., Kim, N. E., Arnett, E. E., Chen, A. C., Sah, R. L., Clark, J. I., Fowler, V. M. Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens PLoS One  2012 7:e48734  DOI:10.1371/journal.pone.0048734  PMID:23144950  PMCID:PMC3492431
  • Ochala, J., Gokhin, D. S., Penisson-Besnier, I., Quijano-Roy, S., Monnier, N., Lunardi, J., Romero, N. B., Fowler, V. M. Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms Human Molecular Genetics  2012 21:4473-4485  DOI:10.1093/hmg/dds289  PMID:22798622  PMCID:PMC3459469
  • Yamashiro, S., Gokhin, D. S., Kimura, S., Nowak, R. B., Fowler, V. M. Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types Cytoskeleton  2012 69:337-370  DOI:10.1002/cm.21031  PMID:22488942  PMCID:PMC3444156
  • Gokhin, D. S., Kim, N. E., Lewis, S. A., Hoenecke, H. R., D'Lima, D. D., Fowler, V. M. Thin-filament length correlates with fiber type in human skeletal muscle American Journal of Physiology-Cell Physiology  2012 302:C555-C565  DOI:10.1152/ajpcell.00299.2011  PMID:22075691  PMCID:PMC3287155
  • Gokhin, D. S., Fowler, V. M. Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers Journal of Cell Biology  2011 194:105-120  DOI:10.1083/jcb.201011128  PMID:21727195  PMCID:PMC3135406
  • Gokhin, D. S., Fowler, V. M. The sarcoplasmic reticulum: actin and tropomodulin hit the links Bioarchitecture  2011 1:175-179  DOI:10.4161/bioa.1.4.17533  PMID:22069510  PMCID:PMC3210515
  • Gokhin, D. S., Fowler, V. M. Tropomodulin capping of actin filaments in striated muscle development and physiology Journal of Biomedicine and Biotechnology  2011 2011:103069  DOI:10.1155/2011/103069  PMID:22013379  PMCID:PMC3196151
  • Gokhin, D. S., Lewis, R. A., McKeown, C. R., Nowak, R. B., Kim, N. E., Littlefield, R. S., Lieber, R. L., Fowler, V. M. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology Journal of Cell Biology  2010 189:95-109  DOI:10.1083/jcb.201001125  PMID:20368620  PMCID:PMC2854367