recent publications
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academic article
- Gokhin, D. S., Nowak, R. B., Khoory, J. A., de la Piedra, A., Ghiran, I. C., Fowler, V. M. Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane Molecular Biology of the Cell 2015 26:1699-1710 DOI:10.1091/mbc.E14-12-1583 PMID:25717184 PMCID:PMC4436781
- Yuen, M., Sandaradura, S. A., Dowling, J. J., Kostyukova, A. S., Moroz, N., Quinlan, K. G., Lehtokari, V. L., Ravenscroft, G., Todd, E. J., Ceyhan-Birsoy, O., Gokhin, D. S., Maluenda, J., et al. Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy Journal of Clinical Investigation 2014 124:4693-4708 DOI:10.1172/jci75199 PMID:25250574
- Gokhin, D. S., Dubuc, E. A., Lian, K. Q., Peters, L. L., Fowler, V. M. Alterations in thin filament length during postnatal skeletal muscle development and aging in mice Frontiers in Physiology 2014 5:375 DOI:10.3389/fphys.2014.00375 PMID:25324783 PMCID:PMC4178374
- Lewis, R. A., Yamashiro, S., Gokhin, D. S., Fowler, V. M. Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3 Cytoskeleton 2014 71:395-411 DOI:10.1002/cm.21179 PMID:24922351 PMCID:PMC4347929
- McKeown, C. R., Nowak, R. B., Gokhin, D. S., Fowler, V. M. Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo Developmental Dynamics 2014 243:800-817 DOI:10.1002/dvdy.24115 PMID:24500875 PMCID:PMC4031292
- Yamashiro, S., Gokhin, D. S., Sui, Z., Bergeron, S. E., Rubenstein, P. A., Fowler, V. M. Differential actin-regulatory activities of Tropomodulin1 and Tropomodulin3 with diverse tropomyosin and actin isoforms Journal of Biological Chemistry 2014 289:11616-11629 DOI:10.1074/jbc.M114.555128 PMID:24644292 PMCID:PMC4002072
- Ochala, J., Gokhin, D. S., Iwamoto, H., Fowler, V. M. Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers FASEB Journal 2014 28:408-415 DOI:10.1096/fj.13-239640 PMID:24072783 PMCID:PMC3868837
- Gokhin, D. S., Fowler, V. M. A two-segment model for thin filament architecture in skeletal muscle Nature Reviews Molecular Cell Biology 2013 14:113-119 DOI:10.1038/nrm3510 PMID:23299957 PMCID:PMC3711620
- Gokhin, D. S., Nowak, R. B., Kim, N. E., Arnett, E. E., Chen, A. C., Sah, R. L., Clark, J. I., Fowler, V. M. Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens PLoS One 2012 7:e48734 DOI:10.1371/journal.pone.0048734 PMID:23144950 PMCID:PMC3492431
- Ochala, J., Gokhin, D. S., Penisson-Besnier, I., Quijano-Roy, S., Monnier, N., Lunardi, J., Romero, N. B., Fowler, V. M. Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms Human Molecular Genetics 2012 21:4473-4485 DOI:10.1093/hmg/dds289 PMID:22798622 PMCID:PMC3459469
- Yamashiro, S., Gokhin, D. S., Kimura, S., Nowak, R. B., Fowler, V. M. Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types Cytoskeleton 2012 69:337-370 DOI:10.1002/cm.21031 PMID:22488942 PMCID:PMC3444156
- Gokhin, D. S., Kim, N. E., Lewis, S. A., Hoenecke, H. R., D'Lima, D. D., Fowler, V. M. Thin-filament length correlates with fiber type in human skeletal muscle American Journal of Physiology-Cell Physiology 2012 302:C555-C565 DOI:10.1152/ajpcell.00299.2011 PMID:22075691 PMCID:PMC3287155
- Gokhin, D. S., Fowler, V. M. Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers Journal of Cell Biology 2011 194:105-120 DOI:10.1083/jcb.201011128 PMID:21727195 PMCID:PMC3135406
- Gokhin, D. S., Fowler, V. M. The sarcoplasmic reticulum: actin and tropomodulin hit the links Bioarchitecture 2011 1:175-179 DOI:10.4161/bioa.1.4.17533 PMID:22069510 PMCID:PMC3210515
- Gokhin, D. S., Fowler, V. M. Tropomodulin capping of actin filaments in striated muscle development and physiology Journal of Biomedicine and Biotechnology 2011 2011:103069 DOI:10.1155/2011/103069 PMID:22013379 PMCID:PMC3196151
- Gokhin, D. S., Lewis, R. A., McKeown, C. R., Nowak, R. B., Kim, N. E., Littlefield, R. S., Lieber, R. L., Fowler, V. M. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology Journal of Cell Biology 2010 189:95-109 DOI:10.1083/jcb.201001125 PMID:20368620 PMCID:PMC2854367